BDBM50024354 CHEMBL3330444::US10106557, Compound 2
SMILES: [H][C@@]12COc3cc(ccc3N1C(=O)O[C@H]2CNC(=O)c1ccc(Cl)s1)N1CCCCC1=O
InChI Key: InChIKey=JCTRHKZXDDIGIB-HOCLYGCPSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Coagulation factor X (Homo sapiens (Human)) | BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 1.93 | n/a | n/a | n/a | n/a | n/a | n/a | 8.3 | n/a |
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent | Assay Description The inhibitory activity on coagulation factor Xa activity in human was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50... | US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.22 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent | Assay Description The activity of the compound to be tested against prothrombinase was determined by the production of thrombin. In summary, 12.5 μL human factor ... | US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Rattus norvegicus (rat)) | BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 4.45 | n/a | n/a | n/a | n/a | n/a | n/a | 8.3 | n/a |
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent | Assay Description The inhibitory activity on coagulation factor Xa activity in rats was measured by using Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl). A buffer of 50 ... | US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent | Assay Description The inhibitory activity on human thrombin was determined by using a buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2). Appropriate wells in the Greiner... | US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trypsin-1 (Homo sapiens (Human)) | BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 8.2 | n/a |
NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. US Patent | Assay Description The inhibitory activity on human trypsin was determined by using buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2). Appropriate wells in the Greiner 384 m... | US Patent US10106557 (2018) BindingDB Entry DOI: 10.7270/Q2X63Q0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor X (Homo sapiens (Human)) | BDBM50024354 (CHEMBL3330444 | US10106557, Compound 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human factor 10a using N-Z-D-Arg-Gly-Arg-pNA, S-2765 chromogenic substrate | J Med Chem 57: 7770-91 (2014) Article DOI: 10.1021/jm501045e BindingDB Entry DOI: 10.7270/Q228095Z | |||||||||||
More data for this Ligand-Target Pair |