BDBM50024710 2-(4-Carboxymethyl-5-oxo-2-thiophen-2-yl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid::CHEMBL300841::Temocaprilat
SMILES: OC(=O)CN1C[C@H](SC[C@H](N[C@@H](CCc2ccccc2)C(O)=O)C1=O)c1cccs1
InChI Key: InChIKey=KZVWEOXAPZXAFB-BQFCYCMXSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Canalicular multispecific organic anion transporter 1 (Rattus norvegicus) | BDBM50024710 (2-(4-Carboxymethyl-5-oxo-2-thiophen-2-yl-[1,4]thia...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 3.43E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd. Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat | J Pharmacol Exp Ther 280: 1304-11 (1997) BindingDB Entry DOI: 10.7270/Q26M37WC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin-converting enzyme (Oryctolagus cuniculus) | BDBM50024710 (2-(4-Carboxymethyl-5-oxo-2-thiophen-2-yl-[1,4]thia...) | MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Sankyo Co., Ltd. Curated by ChEMBL | Assay Description Inhibitory activity against rabbit lung Angiotensin I converting enzyme with 5 mM hippurylhistidylleucine as substrate | J Med Chem 30: 1984-91 (1987) BindingDB Entry DOI: 10.7270/Q2Q52NMJ | |||||||||||
More data for this Ligand-Target Pair |