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BDBM50024997 CHEMBL3143462::CHEMBL7277::p5'(br8A)2'p5'(br8A)2'p5'(br8A)

SMILES: Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12

InChI Key: InChIKey=MGVZUXUOLFXELT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50024997   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RNase L


(Mus musculus)		BDBM50024997
PNG
(CHEMBL3143462 | p5'(br8A)2'p5'(br8A)2'p5'(br8A))
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)O[C@@H]4[C@H](O)[C@@H](COP(O)(=O)O[C@@H]5[C@H](O)[C@@H](COP(O)(=O)O[C@@H]6[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]6n6c(Br)nc7c(N)ncnc67)O[C@H]5n5c(Br)nc6c(N)ncnc56)O[C@H]4n4c(Br)nc5c(N)ncnc45)[C@@H](O)[C@H]3O)c(Br)nc12 |r|
Show InChI InChI=1S/C30H35Br3N15O16P3/c31-28-43-17-20(34)37-7-40-23(17)46(28)16-3-12(49)15(62-16)6-59-67(55,56)64-14-2-11(61-27(14)48-25-19(45-30(48)33)22(36)39-9-42-25)5-58-66(53,54)63-13-1-10(4-57-65(50,51)52)60-26(13)47-24-18(44-29(47)32)21(35)38-8-41-24/h7-16,26-27,49H,1-6H2,(H,53,54)(H,55,56)(H2,34,37,40)(H2,35,38,41)(H2,36,39,42)(H2,50,51,52)
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts

J Med Chem 29: 1015-22 (1986)


BindingDB Entry DOI: 10.7270/Q2SX6C6K
More data for this
Ligand-Target Pair