BDBM50026863 CHEMBL268493::Nicotinamidase Inhibitor, 16::PncA Inhibitor, 2::Pyridine-3-carbaldehyde

SMILES: O=Cc1cccnc1

InChI Key: InChIKey=QJZUKDFHGGYHMC-UHFFFAOYSA-N

Data: 6 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50026863   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamidase (SpNic) (Streptococcus pneumoniae)	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University					Assay Description Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...				Biochemistry 49: 10421-39 (2010) Article DOI: 10.1021/bi1012518 BindingDB Entry DOI: 10.7270/Q2G44NWC
					More data for this Ligand-Target Pair
Nicotinamidase (CePNC2) (Caenorhabditis elegans)	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University					Assay Description Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...				Biochemistry 49: 10421-39 (2010) Article DOI: 10.1021/bi1012518 BindingDB Entry DOI: 10.7270/Q2G44NWC
					More data for this Ligand-Target Pair
Nicotinamidase (BbNic) (Borrelia burgdorferi)	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University					Assay Description Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...				Biochemistry 49: 10421-39 (2010) Article DOI: 10.1021/bi1012518 BindingDB Entry DOI: 10.7270/Q2G44NWC
					More data for this Ligand-Target Pair
Nicotinamidase (CePNC1) (Caenorhabditis elegans)	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University					Assay Description Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...				Biochemistry 49: 10421-39 (2010) Article DOI: 10.1021/bi1012518 BindingDB Entry DOI: 10.7270/Q2G44NWC
					More data for this Ligand-Target Pair
Nicotinamidase (PncA) (Mycobacterium tuberculosis)	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Albert Einstein College of Medicine					Assay Description Enzyme activity measurement by a coupled assay. initial velocities for the reaction of MtPncA were determined by monitoring the loss of absorbance a...				Biochemistry 49: 9613-9 (2010) Article DOI: 10.1021/bi1011157 BindingDB Entry DOI: 10.7270/Q2BC3X52
					More data for this Ligand-Target Pair
Nicotinamidase (Pnc1) (Saccharomyces cerevisiae)	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cornell University					Assay Description Nicotinamidase activity was monitored by coupling the production of ammonia with the consumption of NAD(P)H by the enzyme bovine glutamate dehydrogen...				Biochemistry 49: 10421-39 (2010) Article DOI: 10.1021/bi1012518 BindingDB Entry DOI: 10.7270/Q2G44NWC
					More data for this Ligand-Target Pair
Aldehyde oxidase (Oryctolagus cuniculus)	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol				J Agric Food Chem 59: 4860-7 (2011) Article DOI: 10.1021/jf200485k BindingDB Entry DOI: 10.7270/Q2QF8WR8
					More data for this Ligand-Target Pair
Tyrosinase (Agaricus bisporus (Common mushroom))	BDBM50026863 (CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA...) Show SMILES O=Cc1cccnc1 Show InChI InChI=1S/C6H5NO/c8-5-6-2-1-3-7-4-6/h1-5H	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of Agaricus bisporus (mushroom) tyrosinase				J Agric Food Chem 59: 4860-7 (2011) Article DOI: 10.1021/jf200485k BindingDB Entry DOI: 10.7270/Q2QF8WR8
					More data for this Ligand-Target Pair