BDBM50026953 (cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-piperazin-1-yl}-propan-1-ol; Dihydrochloride::(trans) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-piperazin-1-yl}-propan-1-ol::CHEMBL176506
SMILES: OCCCN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
InChI Key: InChIKey=DFXIUCBFFHVYGQ-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50026953 ((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Effect on synaptosomal uptake inhibition of Noradrenaline (NA) | J Med Chem 26: 935-47 (1983) BindingDB Entry DOI: 10.7270/Q2JH3MR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50026953 ((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT) | J Med Chem 26: 935-47 (1983) BindingDB Entry DOI: 10.7270/Q2JH3MR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus) | BDBM50026953 ((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Effect on synaptosomal uptake inhibition of Noradrenaline (NA) | J Med Chem 26: 935-47 (1983) BindingDB Entry DOI: 10.7270/Q2JH3MR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50026953 ((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Effect on synaptosomal uptake inhibition of Dopamine receptor | J Med Chem 26: 935-47 (1983) BindingDB Entry DOI: 10.7270/Q2JH3MR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50026953 ((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Effect on synaptosomal uptake inhibition of 5-hydroxytryptamine (5-HT) | J Med Chem 26: 935-47 (1983) BindingDB Entry DOI: 10.7270/Q2JH3MR6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dopamine receptor (Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...) | BDBM50026953 ((cis) 3-{4-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-pi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Effect on synaptosomal uptake inhibition of Dopamine receptor | J Med Chem 26: 935-47 (1983) BindingDB Entry DOI: 10.7270/Q2JH3MR6 | |||||||||||
More data for this Ligand-Target Pair |