BindingDB PrimarySearch

null

SMILES: CN1C[C@@H](C=C2[C@H]1Cc1c[nH]c3cccc2c13)C(=O)N[C@]1(C)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O

InChI Key: InChIKey=XCGSFFUVFURLIX-VFGNJEKYSA-N

PDB links: 6 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 68 hits for monomerid = 50027065
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (RAT)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	107	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by PDSP K_i Database									Neuropharmacology 36: 713-20 (1997) Article DOI: 10.1016/s0028-3908(97)00019-1 BindingDB Entry DOI: 10.7270/Q2MW2FP8
F. Hoffmann-La Roche Ltd. Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (GUINEA PIG)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	138	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Syntex Discovery Research Curated by PDSP K_i Database									Br J Pharmacol 115: 107-16 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb16327.x BindingDB Entry DOI: 10.7270/Q2610XTR
Syntex Discovery Research Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	155	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Albany Medical College Curated by PDSP K_i Database									J Neurochem 53: 465-71 (1989) Article DOI: 10.1111/j.1471-4159.1989.tb07357.x BindingDB Entry DOI: 10.7270/Q20000K7
Albany Medical College Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by PDSP K_i Database									Neuropharmacology 33: 275-317 (1994) Article DOI: 10.1016/0028-3908(94)90059-0 BindingDB Entry DOI: 10.7270/Q2M043X2
University of Alberta Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1F (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	171	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synaptic Pharmaceutical Corporation Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 90: 408-12 (1993) Article DOI: 10.1073/pnas.90.2.408 BindingDB Entry DOI: 10.7270/Q2862DZF
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	537	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by PDSP K_i Database									Neuropharmacology 33: 275-317 (1994) Article DOI: 10.1016/0028-3908(94)90059-0 BindingDB Entry DOI: 10.7270/Q2M043X2
University of Alberta Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	575	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by PDSP K_i Database									Neuropharmacology 33: 275-317 (1994) Article DOI: 10.1016/0028-3908(94)90059-0 BindingDB Entry DOI: 10.7270/Q2M043X2
University of Alberta Curated by PDSP K_i Database					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	599	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Synaptic Pharmaceutical Corporation Curated by PDSP K_i Database									Mol Pharmacol 42: 180-5 (1992) BindingDB Entry DOI: 10.7270/Q2416VJ0
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (RAT)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by PDSP K_i Database									Proc Natl Acad Sci U S A 90: 2184-8 (1993) Article DOI: 10.1073/pnas.90.6.2184 BindingDB Entry DOI: 10.7270/Q2765CVH
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1E (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	603	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by PDSP K_i Database									Neuropharmacology 33: 275-317 (1994) Article DOI: 10.1016/0028-3908(94)90059-0 BindingDB Entry DOI: 10.7270/Q2M043X2
University of Alberta Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Beta-2 adrenergic receptor (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Mol Pharmacol 12: 568-80 (1976) BindingDB Entry DOI: 10.7270/Q2ZK5F5P
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cells				Mol Pharmacol 61: 964-73 (2002) BindingDB Entry DOI: 10.7270/Q2W95B7Z
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Mus musculus)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1b-expressing LLC-PK1 cells				J Pharmacol Exp Ther 303: 323-32 (2002) Article DOI: 10.1124/jpet.102.037549 BindingDB Entry DOI: 10.7270/Q2NZ8BH2
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Homo sapiens (Human))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	9.89E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells				Mol Pharmacol 61: 964-73 (2002) BindingDB Entry DOI: 10.7270/Q2W95B7Z
Lilly Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
ATP-dependent translocase ABCB1 (Mus musculus (Mouse))	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.89E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in mdr1a-expressing LLC-PK1 cells				J Pharmacol Exp Ther 303: 323-32 (2002) Article DOI: 10.1124/jpet.102.037549 BindingDB Entry DOI: 10.7270/Q2NZ8BH2
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gastrin/cholecystokinin type B receptor (MOUSE)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKB in mouse fore brain membranes				Bioorg Med Chem Lett 2: 9-12 (1992) Article DOI: 10.1016/S0960-894X(00)80644-7 BindingDB Entry DOI: 10.7270/Q29P3242
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Cholecystokinin receptor type A (Mus musculus)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration of compound required to inhibit binding of [125I]J-BH-CCK-8 radioligand to CCKA in mouse pancreatic membranes				Bioorg Med Chem Lett 2: 9-12 (1992) Article DOI: 10.1016/S0960-894X(00)80644-7 BindingDB Entry DOI: 10.7270/Q29P3242
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate cyclase (Spirulina platensis)	BDBM50027065 ((5'alpha)-12'-hydroxy-2'-methyl-5'-(phenylmethyl)e...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Ruhr-University Bochum Curated by ChEMBL					Assay Description Inhibition of Spirulina platensis adenylyl cyclase assessed as cAMP level by cAMP immunogenic assay				J Med Chem 51: 4456-64 (2008) Article DOI: 10.1021/jm800481q BindingDB Entry DOI: 10.7270/Q22N5355
Ruhr-University Bochum Curated by ChEMBL					More data for this Ligand-Target Pair

<< First | Previous | Displayed 51 to 68 (of 68 total )