BindingDB PrimarySearch

BDBM50027216 5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,2-diphenylpentanenitrile::5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile::CHEMBL34166::VUF-2274

SMILES: OC1(CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1

InChI Key: InChIKey=MEEJEEVTIVAOJP-UHFFFAOYSA-N

Data: 1 KI 6 IC50 5 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50027216
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cells				J Med Chem 42: 4680-94 (1999) BindingDB Entry DOI: 10.7270/Q2125TCC
Berlex Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.				J Med Chem 44: 1429-35 (2001) BindingDB Entry DOI: 10.7270/Q2G73D0G
					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells				J Med Chem 45: 3794-804 (2002) BindingDB Entry DOI: 10.7270/Q2MW2GG0
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 3 (Homo sapiens (Human))	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells				J Med Chem 45: 3794-804 (2002) BindingDB Entry DOI: 10.7270/Q2MW2GG0
Bristol-Myers Squibb Company Curated by ChEMBL					More data for this Ligand-Target Pair
Human herpesvirus 5 chemokine receptor (Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by PDSP K_i Database					Assay Description Inhibitory concentration against chemokine receptor US28 expressed in COS-7 cells using [125I]-CCL5				J Med Chem 48: 6461-71 (2005) Article DOI: 10.1021/jm050418d BindingDB Entry DOI: 10.7270/Q2ZP4640
Vrije Universiteit Curated by PDSP K_i Database					More data for this Ligand-Target Pair
G protein-coupled receptor (Human cytomegalovirus)	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Friedrich Alexander University Curated by ChEMBL					Assay Description Allosteric modulatory activity at FLAG-tagged human cytomegalovirus US28 receptor delta300 mutant expressed in HEK293T cells by PathDetectElk1 assay				Bioorg Med Chem Lett 24: 3744-7 (2014) Article DOI: 10.1016/j.bmcl.2014.06.082 BindingDB Entry DOI: 10.7270/Q27H1NJC
Friedrich Alexander University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Homo sapiens (Human))	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor				J Med Chem 42: 4680-94 (1999) BindingDB Entry DOI: 10.7270/Q2125TCC
Berlex Biosciences Curated by ChEMBL					More data for this Ligand-Target Pair
Human herpesvirus 5 chemokine receptor (Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.57E+3	n/a	n/a	n/a	n/a
Friedrich Alexander University Curated by ChEMBL					Assay Description Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay				Bioorg Med Chem Lett 24: 3744-7 (2014) Article DOI: 10.1016/j.bmcl.2014.06.082 BindingDB Entry DOI: 10.7270/Q27H1NJC
Friedrich Alexander University Curated by ChEMBL					More data for this Ligand-Target Pair
Human herpesvirus 5 chemokine receptor (Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a
Friedrich Alexander University Curated by ChEMBL					Assay Description Allosteric modulatory activity at FLAG-tagged wild type human cytomegalovirus US28 receptor expressed in HEK293T cells by PathDetectElk1 assay				Bioorg Med Chem Lett 24: 3744-7 (2014) Article DOI: 10.1016/j.bmcl.2014.06.082 BindingDB Entry DOI: 10.7270/Q27H1NJC
Friedrich Alexander University Curated by ChEMBL					More data for this Ligand-Target Pair
G protein-coupled receptor (Human cytomegalovirus)	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a
Friedrich Alexander University Curated by ChEMBL					Assay Description Allosteric modulatory activity at FLAG-tagged human cytomegalovirus US28 receptor delta300 mutant expressed in HEK293T cells by PathDetectElk1 assay				Bioorg Med Chem Lett 24: 3744-7 (2014) Article DOI: 10.1016/j.bmcl.2014.06.082 BindingDB Entry DOI: 10.7270/Q27H1NJC
Friedrich Alexander University Curated by ChEMBL					More data for this Ligand-Target Pair
C-C chemokine receptor type 1 (Mus musculus)	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.				J Med Chem 44: 1429-35 (2001) BindingDB Entry DOI: 10.7270/Q2G73D0G
					More data for this Ligand-Target Pair
Human herpesvirus 5 chemokine receptor (Human cytomegalovirus (strain AD169) (HHV-5) (Huma...)	BDBM50027216 (5-(4-(4-chlorophenyl)-4-hydroxy-piperidin-1-yl)-2,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by PDSP K_i Database					Assay Description Effective concentration against US28-mediated inositol phosphate production in COS-7 cells				J Med Chem 48: 6461-71 (2005) Article DOI: 10.1021/jm050418d BindingDB Entry DOI: 10.7270/Q2ZP4640
Vrije Universiteit Curated by PDSP K_i Database					More data for this Ligand-Target Pair