BDBM50027536 (phosphonoformate)Trisodium phosphonoformate::Antiviral agent : Inhibitor of reverse transcriptase of Human T-cell lymphotropic, virus type III, useful in the treatment of HSV-1 infections::CHEMBL754::EHB-776::FOSCARNET SODIUM::Foscarnet::Foscavir::phosphonoformate trisodium salt::trisodium dioxidophosphinecarboxylate oxide::trisodium dioxidophosphinecarboxylate oxide with 6 molecules of water(foscarnet)::trisodium phosphonoformate

SMILES: [O-]C(=O)P([O-])([O-])=O

InChI Key: InChIKey=ZJAOAACCNHFJAH-UHFFFAOYSA-K

Data: 14 KI  7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50027536   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 7 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	5.60E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA7 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA IV				Bioorg Med Chem Lett 14: 5763-7 (2004) Article DOI: 10.1016/j.bmcl.2004.09.064 BindingDB Entry DOI: 10.7270/Q2V40TPN
					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA4 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic Anhydrase XIII (Mus musculus (mouse))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	8.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of mouse recombinant CA13 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.29E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA12 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 6 (CA-VI) (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.81E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA6 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.21E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA IX				Bioorg Med Chem Lett 14: 5763-7 (2004) Article DOI: 10.1016/j.bmcl.2004.09.064 BindingDB Entry DOI: 10.7270/Q2V40TPN
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.21E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA9 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic Anhydrase XIV (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	3.60E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA14 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic Anhydrase VB (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.18E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA5B by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.42E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA2 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	1.42E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Università degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition constant of anion against human carbonic anhydrase isozyme hCA II				Bioorg Med Chem Lett 14: 5763-7 (2004) Article DOI: 10.1016/j.bmcl.2004.09.064 BindingDB Entry DOI: 10.7270/Q2V40TPN
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	2.41E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of cloned human CA1 by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Carbonic Anhydrase VA (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	4.17E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Firenze Curated by ChEMBL					Assay Description Inhibition of human recombinant CA5A by CO2 hydration assay				Bioorg Med Chem Lett 17: 2210-5 (2007) Article DOI: 10.1016/j.bmcl.2007.01.113 BindingDB Entry DOI: 10.7270/Q21C1XP7
					More data for this Ligand-Target Pair
Multidrug resistance-associated protein 4 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 2 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Canalicular multispecific organic anion transporter 1 (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Life Science Research Center Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 reverse transcriptase				J Med Chem 40: 2363-73 (1997) Article DOI: 10.1021/jm9607921 BindingDB Entry DOI: 10.7270/Q2TB161T
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Bile salt export pump (Homo sapiens (Human))	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc Curated by ChEMBL					Assay Description Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...				Toxicol Sci 136: 216-41 (2013) BindingDB Entry DOI: 10.7270/Q2JM2D2D
					More data for this Ligand-Target Pair
Human herpesvirus 1 DNA polymerase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...)	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay				J Med Chem 26: 264-70 (1983) BindingDB Entry DOI: 10.7270/Q2RN36VT
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Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50027536 ((phosphonoformate)Trisodium phosphonoformate | Ant...) Show SMILES [O-]C(=O)P([O-])([O-])=O Show InChI InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)/p-3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
Life Science Research Center Curated by ChEMBL					Assay Description Inhibitory effect of the compound on Molony Murine Leukemia virus (mo-MuLv) Recombiannt Reverse transcriptase				J Med Chem 40: 2363-73 (1997) Article DOI: 10.1021/jm9607921 BindingDB Entry DOI: 10.7270/Q2TB161T
					More data for this Ligand-Target Pair