BDBM50027776 4-Ethynyl Biphenyl::4-Ethynyl-Biphenyl::CHEMBL374163
SMILES: C#Cc1ccc(cc1)-c1ccccc1
InChI Key: InChIKey=BPBNKCIVWFCMJY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cytochrome P450 1A1 (Rattus norvegicus) | BDBM50027776 (4-Ethynyl Biphenyl | 4-Ethynyl-Biphenyl | CHEMBL37...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Mechanism based inhibition of rat cytochrome P450 CYP1A1 measured by 7-ethoxyresorufin O-deethylation (EROD) | Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 1A2 (Rattus norvegicus) | BDBM50027776 (4-Ethynyl Biphenyl | 4-Ethynyl-Biphenyl | CHEMBL37...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 870 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Mechanism based inhibition of rat cytochrome P450 CYP1A2 measured by 7-methoxyresorufin O-demethylation (MROD) | Curr Drug Metab 6: 413-54 (2005) BindingDB Entry DOI: 10.7270/Q2VQ33X3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
O-GlcNAc Transferase (OGT) (Homo sapiens (Human)) | BDBM50027776 (4-Ethynyl Biphenyl | 4-Ethynyl-Biphenyl | CHEMBL37...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of OGT (unknown origin) assessed as reduction in GlcNAc transfer to CKII peptide incubated for 60 mins by HPLC method | J Med Chem 60: 263-272 (2017) Article DOI: 10.1021/acs.jmedchem.6b01237 BindingDB Entry DOI: 10.7270/Q20G3N47 | |||||||||||
More data for this Ligand-Target Pair |