BDBM50028191 (R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione::7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione::CHEMBL37019

SMILES: C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12

InChI Key: InChIKey=KYHQZNGJUGFTGR-ZCFIWIBFSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50028191   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50028191 ((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3/t6-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung high-affinity cGMP phosphodiesterases (0.5-2 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50028191 ((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3/t6-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50028191 ((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...) Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3/t6-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against rabbit lung indole N-methyl-transferase by using S-adenosyl-L-[methyl-3H]-methionine as radioligand.				J Med Chem 26: 1514-8 (1983) BindingDB Entry DOI: 10.7270/Q21Z43F5
					More data for this Ligand-Target Pair