BDBM50028350 6-(3,4-Dimethyl-phenylamino)-1H-pyrimidine-2,4-dione::CHEMBL54782

SMILES: Cc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1C

InChI Key: InChIKey=DXOQUXIEIBVQHC-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50028350   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA topoisomerase III (Bacillus subtilis)	BDBM50028350 (6-(3,4-Dimethyl-phenylamino)-1H-pyrimidine-2,4-dio...) Show SMILES Cc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1C Show InChI InChI=1S/C12H13N3O2/c1-7-3-4-9(5-8(7)2)13-10-6-11(16)15-12(17)14-10/h3-6H,1-2H3,(H3,13,14,15,16,17)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition against Bacillus subtilis DNA topoisomerase III (wild type)				J Med Chem 23: 34-8 (1980) BindingDB Entry DOI: 10.7270/Q2125RPK
					More data for this Ligand-Target Pair
DNA topoisomerase III (Bacillus subtilis)	BDBM50028350 (6-(3,4-Dimethyl-phenylamino)-1H-pyrimidine-2,4-dio...) Show SMILES Cc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1C Show InChI InChI=1S/C12H13N3O2/c1-7-3-4-9(5-8(7)2)13-10-6-11(16)15-12(17)14-10/h3-6H,1-2H3,(H3,13,14,15,16,17)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition constant against Bacillus subtilis DNA topoisomerase III (wild type).				J Med Chem 27: 181-5 (1984) BindingDB Entry DOI: 10.7270/Q2Q241FK
					More data for this Ligand-Target Pair
DNA topoisomerase III (Bacillus subtilis)	BDBM50028350 (6-(3,4-Dimethyl-phenylamino)-1H-pyrimidine-2,4-dio...) Show SMILES Cc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1C Show InChI InChI=1S/C12H13N3O2/c1-7-3-4-9(5-8(7)2)13-10-6-11(16)15-12(17)14-10/h3-6H,1-2H3,(H3,13,14,15,16,17)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition constant against Bacillus subtilis azp-12 DNA topoisomerase III (mutant enzyme).				J Med Chem 27: 181-5 (1984) BindingDB Entry DOI: 10.7270/Q2Q241FK
					More data for this Ligand-Target Pair
DNA polymerase IIIC (Bacillus subtilis)	BDBM50028350 (6-(3,4-Dimethyl-phenylamino)-1H-pyrimidine-2,4-dio...) Show SMILES Cc1ccc(Nc2cc(=O)[nH]c(=O)[nH]2)cc1C Show InChI InChI=1S/C12H13N3O2/c1-7-3-4-9(5-8(7)2)13-10-6-11(16)15-12(17)14-10/h3-6H,1-2H3,(H3,13,14,15,16,17)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibition of Bacillus subtilis DNA Polymerase III/azp-12(mutant).				J Med Chem 23: 34-8 (1980) BindingDB Entry DOI: 10.7270/Q2125RPK
					More data for this Ligand-Target Pair