BDBM50028535 CHEMBL55797::derivative of methotrexate
SMILES: CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O
InChI Key: InChIKey=FACPCDZDGSEZOG-LOACHALJSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Mus musculus (Mouse)) | BDBM50028535 (CHEMBL55797 | derivative of methotrexate) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | 208 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Dihydrofolate reductase in mouse L1210 cells | J Med Chem 25: 182-7 (1982) BindingDB Entry DOI: 10.7270/Q2KS6QJZ | |||||||||||
More data for this Ligand-Target Pair |