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SMILES: O=c1n(-c2ccccc2)c(=S)[nH]c2ccccc12

InChI Key: InChIKey=CRGOYNYLYMPGKH-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50028895   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A


(Homo sapiens (Human))		BDBM50028895
PNG
(CHEMBL451589)
Show SMILES O=c1n(-c2ccccc2)c(=S)[nH]c2ccccc12
Show InChI InChI=1S/C14H10N2OS/c17-13-11-8-4-5-9-12(11)15-14(18)16(13)10-6-2-1-3-7-10/h1-9H,(H,15,18)
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Article
PubMed
n/an/a 4.68E+3n/an/an/an/an/an/a



Centro de Investigaciones Biol�gicas (CSIC)

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE7A1 assessed as inhibition of hydrolysis of [3H]cAMP after 20 mins by scintillation proximity assay

J Med Chem 57: 8590-607 (2014)


Article DOI: 10.1021/jm501090m
BindingDB Entry DOI: 10.7270/Q2S75HXC
More data for this
Ligand-Target Pair