Found 37 hits for monomerid = 50028962 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Amine oxidase [flavin-containing] B
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
UniProtKB/SwissProt
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| Article PubMed
| 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology
| Assay Description The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =... |
Bioorg Chem 58: 72-80 (2015)
Article DOI: 10.1016/j.bioorg.2014.11.008 BindingDB Entry DOI: 10.7270/Q2PG1QFJ |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 1.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 12 hrs by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Amine oxidase (flavin-containing) A
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Birla Institute of Technology
| Assay Description The activities of recombinant hMAO-A and hMAO-B were determined using p-tyramine as common substrate and calculated as 0.18 +/- 0.01 nmol/mg/min (n =... |
Bioorg Chem 58: 72-80 (2015)
Article DOI: 10.1016/j.bioorg.2014.11.008 BindingDB Entry DOI: 10.7270/Q2PG1QFJ |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
Reactome pathway KEGG
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| Article PubMed
| 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Displacement of specific [3H]-PIA binding from adenosine A1 receptor in rat brain membranes. |
J Med Chem 39: 781-8 (1996)
Article DOI: 10.1021/jm950661k BindingDB Entry DOI: 10.7270/Q2M32TV4 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
Reactome pathway KEGG
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| 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]-PIA displacement. |
J Med Chem 39: 2293-301 (1996)
Article DOI: 10.1021/jm950923i BindingDB Entry DOI: 10.7270/Q2D799J2 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
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| 3.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Ability to displace [3H]N6-phenylisopropyladenosine binding from adenosine A1 receptor. |
J Med Chem 41: 46-52 (1998)
Checked by Author Article DOI: 10.1021/jm970446z BindingDB Entry DOI: 10.7270/Q2NC62QT |
More data for this Ligand-Target Pair | |
Adenosine Receptors A2a (A2a)
(Rattus norvegicus (rat)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| 3.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement. |
J Med Chem 39: 781-8 (1996)
Article DOI: 10.1021/jm950661k BindingDB Entry DOI: 10.7270/Q2M32TV4 |
More data for this Ligand-Target Pair | |
Adenosine Receptors A2a (A2a)
(Rattus norvegicus (rat)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| 3.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor. |
J Med Chem 41: 46-52 (1998)
Checked by Author Article DOI: 10.1021/jm970446z BindingDB Entry DOI: 10.7270/Q2NC62QT |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 4.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 9
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
NCI pathway Reactome pathway KEGG
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| 4.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 12 hrs by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 12
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 7.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 12
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| 7.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 12 hrs by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| 8.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Carbonic anhydrase 2
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Cagliari
Curated by ChEMBL
| Assay Description Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 12 hrs by stopped flow CO2 hydration assay |
Bioorg Med Chem Lett 22: 3063-6 (2012)
Article DOI: 10.1016/j.bmcl.2012.03.071 BindingDB Entry DOI: 10.7270/Q2J1045T |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | Reactome pathway KEGG
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| 1.69E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]-AB-MECA 21680 radioligand. |
J Med Chem 39: 2293-301 (1996)
Article DOI: 10.1021/jm950923i BindingDB Entry DOI: 10.7270/Q2D799J2 |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | Reactome pathway KEGG
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| Article PubMed
| 1.69E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Displacement of [125I]-AB-MECA binding to human Adenosine A3 receptor expressed in HEK-293 cells |
J Med Chem 39: 781-8 (1996)
Article DOI: 10.1021/jm950661k BindingDB Entry DOI: 10.7270/Q2M32TV4 |
More data for this Ligand-Target Pair | |
Adenosine receptor A3
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | Reactome pathway KEGG
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| 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Ability to displace [125I]-AB-MECA binding from adenosine A3 receptor. |
J Med Chem 41: 46-52 (1998)
Checked by Author Article DOI: 10.1021/jm970446z BindingDB Entry DOI: 10.7270/Q2NC62QT |
More data for this Ligand-Target Pair | |
Cytochrome P450 1B1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec - Research Center, Québec, Québec, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval,
Curated by ChEMBL
| Assay Description Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in pre... |
Eur J Med Chem 135: 296-306 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.042 BindingDB Entry DOI: 10.7270/Q26Q20QW |
More data for this Ligand-Target Pair | |
Androgen receptor
(Rattus norvegicus (Rat)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
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| n/a | n/a | 7.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Basel
Curated by ChEMBL
| Assay Description Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) |
J Med Chem 48: 5666-74 (2005)
Article DOI: 10.1021/jm050403f BindingDB Entry DOI: 10.7270/Q2TM7CBZ |
More data for this Ligand-Target Pair | |
Dihydroorotate dehydrogenase
(Saccharomyces cerevisiae) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard School of Public Health
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae DHOD |
Bioorg Med Chem Lett 19: 972-5 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.071 BindingDB Entry DOI: 10.7270/Q2Z89DBX |
More data for this Ligand-Target Pair | |
Dihydroorotate Dehydrogenase (DHODH)
(Plasmodium falciparum) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard School of Public Health
Curated by ChEMBL
| Assay Description Inhibition of Plasmodium falciparum DHOD |
Bioorg Med Chem Lett 19: 972-5 (2009)
Article DOI: 10.1016/j.bmcl.2008.11.071 BindingDB Entry DOI: 10.7270/Q2Z89DBX |
More data for this Ligand-Target Pair | |
Cytochrome P450 19A1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University
Curated by ChEMBL
| Assay Description Inhibition of human placental microsome CYP19 |
Bioorg Med Chem Lett 20: 3050-64 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.113 BindingDB Entry DOI: 10.7270/Q2CJ8FFS |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
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| PDB Article PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu
Curated by ChEMBL
| Assay Description Inhibition of human 6XHis-tagged TNKS1 SAM-ART domain (1030 to 1317 amino acid residues) by fluorescence assay |
J Med Chem 56: 3507-17 (2013)
Article DOI: 10.1021/jm3018783 BindingDB Entry DOI: 10.7270/Q24M95W6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
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| PDB Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu
Curated by ChEMBL
| Assay Description Inhibition of human 6XHis-tagged TNKS2 ART domain (946 to 1161 amino acid residues) expressed in Escherichia coli Rosetta2 (DE3) by fluorescence assa... |
J Med Chem 56: 3507-17 (2013)
Article DOI: 10.1021/jm3018783 BindingDB Entry DOI: 10.7270/Q24M95W6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oulu
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ARTD1 by fluorescence assay |
J Med Chem 56: 3507-17 (2013)
Article DOI: 10.1021/jm3018783 BindingDB Entry DOI: 10.7270/Q24M95W6 |
More data for this Ligand-Target Pair | |
P-glycoprotein 1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| n/a | n/a | n/a | 3.39E+4 | n/a | n/a | n/a | n/a | n/a |
Chosun University
Curated by ChEMBL
| Assay Description Binding affinity to ABCB1 nucleotide binding domain 2 |
Eur J Med Chem 46: 4078-88 (2011)
Article DOI: 10.1016/j.ejmech.2011.06.008 BindingDB Entry DOI: 10.7270/Q2FJ2J3W |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase 4
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins ... |
Eur J Med Chem 151: 145-157 (2018)
Article DOI: 10.1016/j.ejmech.2018.03.041 BindingDB Entry DOI: 10.7270/Q2CZ39SV |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family G member 2
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
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| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining |
Bioorg Med Chem 19: 2090-102 (2011)
Article DOI: 10.1016/j.bmc.2010.12.043 BindingDB Entry DOI: 10.7270/Q2PZ593F |
More data for this Ligand-Target Pair | |
Calmodulin
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | 1.02E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma del Estado de Morelos
Curated by ChEMBL
| Assay Description Inhibition of human recombinant calmodulin assessed as inhibition of calmodulin-sensitive cAMP phosphodiesterase activation after 15 mins by spectrop... |
Bioorg Med Chem 19: 542-6 (2011)
Article DOI: 10.1016/j.bmc.2010.10.063 BindingDB Entry DOI: 10.7270/Q2KH0NM0 |
More data for this Ligand-Target Pair | |
Androgen Receptor
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Meijo University
Curated by ChEMBL
| Assay Description Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene... |
Bioorg Med Chem Lett 19: 4706-10 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.073 BindingDB Entry DOI: 10.7270/Q26T0MNQ |
More data for this Ligand-Target Pair | |
Cytochrome P450 19A1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
American University of Ras Al Khaimah
Curated by ChEMBL
| Assay Description Inhibition of aromatase (unknown origin) |
Eur J Med Chem 102: 375-86 (2015)
BindingDB Entry DOI: 10.7270/Q2ZC84Q6 |
More data for this Ligand-Target Pair | |
ATP-binding cassette sub-family G member 2
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining |
Bioorg Med Chem 19: 2090-102 (2011)
Article DOI: 10.1016/j.bmc.2010.12.043 BindingDB Entry DOI: 10.7270/Q2PZ593F |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
KEGG
UniProtKB/SwissProt
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of EGFR in human A431 cells |
J Nat Prod 55: 1529-1560 (1992)
Article DOI: 10.1021/np50089a001 BindingDB Entry DOI: 10.7270/Q2J966CC |
More data for this Ligand-Target Pair | |
DNA-dependent protein kinase catalytic subunit
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB
KEGG
UniProtKB/SwissProt
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Patents
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University
Curated by ChEMBL
| Assay Description Inhibition of DNA dependent protein kinase isolated from HeLa cells |
J Med Chem 48: 569-85 (2005)
Article DOI: 10.1021/jm049526a BindingDB Entry DOI: 10.7270/Q2BK1BV9 |
More data for this Ligand-Target Pair | |
Dipeptidyl peptidase III
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
KEGG
UniProtKB/SwissProt
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Patents
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| n/a | n/a | 2.93E+5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Josip Juraj Strossmayer University of Osijek
| Assay Description The inhibitory activity of flavonoids toward human DPP III was assayed in a 50 mM Tris-HCl buffer, pH 7.4. In brief, recombinant human DPP III (0.29 ... |
Chem Biol Drug Des 89: 619-627 (2017)
Article DOI: 10.1111/cbdd.12887 BindingDB Entry DOI: 10.7270/Q2X34WBS |
More data for this Ligand-Target Pair | |
Cytochrome P450 19A1
(Homo sapiens (Human)) | BDBM50028962
(CHEMBL275638 | flavone)Show InChI InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Patents
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Kentucky University
Curated by ChEMBL
| Assay Description Inhibition of aromatase (unknown origin) |
Bioorg Med Chem 22: 126-34 (2013)
Article DOI: 10.1016/j.bmc.2013.11.045 BindingDB Entry DOI: 10.7270/Q2D79CXT |
More data for this Ligand-Target Pair | |