BDBM50029778 CHEMBL264717::N-{3-[5-(4-fluorophenoxy)-2-furyl]prop-2-ynyl}-N-hydroxyurea::N-{3-[5-(4-fluorophenoxy)furan-2-yl]prop-2-ynyl}-N-hydroxyurea

SMILES: NC(=O)N(O)CC#Cc1ccc(Oc2ccc(F)cc2)o1

InChI Key: InChIKey=LMKILXJEWYALMW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50029778   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50029778 (CHEMBL264717 | N-{3-[5-(4-fluorophenoxy)-2-furyl]p...) Show SMILES NC(=O)N(O)CC#Cc1ccc(Oc2ccc(F)cc2)o1 Show InChI InChI=1S/C14H11FN2O4/c15-10-3-5-12(6-4-10)21-13-8-7-11(20-13)2-1-9-17(19)14(16)18/h3-8,19H,9H2,(H2,16,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description 5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...				J Med Chem 38: 4768-75 (1996) BindingDB Entry DOI: 10.7270/Q2V40VV9
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Homo sapiens (Human))	BDBM50029778 (CHEMBL264717 | N-{3-[5-(4-fluorophenoxy)-2-furyl]p...) Show SMILES NC(=O)N(O)CC#Cc1ccc(Oc2ccc(F)cc2)o1 Show InChI InChI=1S/C14H11FN2O4/c15-10-3-5-12(6-4-10)21-13-8-7-11(20-13)2-1-9-17(19)14(16)18/h3-8,19H,9H2,(H2,16,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).				J Med Chem 40: 1955-68 (1997) Article DOI: 10.1021/jm9700474 BindingDB Entry DOI: 10.7270/Q2NV9JWT
					More data for this Ligand-Target Pair