BDBM50030145 CHEMBL290701::bis-(1N-[4-cyclopropylmethyl-10-hydroxy-14-oxo-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-17-yl]-2-sulfanylacetamide)
SMILES: Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35NC(=O)CSSCC(=O)N[C@]12CCC(=O)[C@@H]3Oc4c5c(C[C@H]1N(CC1CC1)CC[C@@]235)ccc4O
InChI Key: InChIKey=CYNYZGWJRWHWPG-CTHHFRLWSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50030145 (CHEMBL290701 | bis-(1N-[4-cyclopropylmethyl-10-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity of the compound against Opioid receptor delta 1 binding to bovine striatal membrane | Bioorg Med Chem Lett 5: 1695-1700 (1995) Article DOI: 10.1016/0960-894X(95)00287-4 BindingDB Entry DOI: 10.7270/Q2125SNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50030145 (CHEMBL290701 | bis-(1N-[4-cyclopropylmethyl-10-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity of the compound against Opioid receptor kappa1 binding to bovine striatal membrane | Bioorg Med Chem Lett 5: 1695-1700 (1995) Article DOI: 10.1016/0960-894X(95)00287-4 BindingDB Entry DOI: 10.7270/Q2125SNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50030145 (CHEMBL290701 | bis-(1N-[4-cyclopropylmethyl-10-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Evaluation for the inhibition of kappa opioid binding to bovine striatal membranes by the affinity ligand 1 nM [3H]U-69593 radiolabeled opioid | J Med Chem 37: 1578-85 (1994) BindingDB Entry DOI: 10.7270/Q29024FN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50030145 (CHEMBL290701 | bis-(1N-[4-cyclopropylmethyl-10-hyd...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Evaluation for the inhibition of delta opioid binding to bovine striatal membranes by the affinity ligand 0.2 nM [3H]-p-Cl-DPDPE radiolabeled opioid | J Med Chem 37: 1578-85 (1994) BindingDB Entry DOI: 10.7270/Q29024FN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (CALF) | BDBM50030145 (CHEMBL290701 | bis-(1N-[4-cyclopropylmethyl-10-hyd...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute Curated by ChEMBL | Assay Description Evaluation for the inhibition of mu opioid binding to bovine striatal membranes by the affinity ligand 0.25 nM [3H]DAMGO radiolabeled opioid | J Med Chem 37: 1578-85 (1994) BindingDB Entry DOI: 10.7270/Q29024FN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (CALF) | BDBM50030145 (CHEMBL290701 | bis-(1N-[4-cyclopropylmethyl-10-hyd...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity of the compound against Opioid receptor mu 1 binding to bovine striatal membrane | Bioorg Med Chem Lett 5: 1695-1700 (1995) Article DOI: 10.1016/0960-894X(95)00287-4 BindingDB Entry DOI: 10.7270/Q2125SNJ | |||||||||||
More data for this Ligand-Target Pair |