Found 14 hits for monomerid = 50030628 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor
(RAT) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article PubMed
| 1.65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development, Beerse
Curated by PDSP Ki Database
| |
Mol Pharmacol 63: 1082-93 (2003)
Article DOI: 10.1124/mol.63.5.1082 BindingDB Entry DOI: 10.7270/Q2BV7F62 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche
Curated by PDSP Ki Database
| |
J Neurochem 75: 2590-601 (2000)
Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB MMDB
KEGG
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by PDSP Ki Database
| |
Annu Rev Pharmacol Toxicol 37: 205-37 (1997)
Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UPR Centre
Curated by PDSP Ki Database
| |
Mol Pharmacol 50: 923-30 (1996)
BindingDB Entry DOI: 10.7270/Q2M61HS5 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by PDSP Ki Database
| |
Annu Rev Pharmacol Toxicol 37: 205-37 (1997)
Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University
Curated by PDSP Ki Database
| |
Annu Rev Pharmacol Toxicol 37: 205-37 (1997)
Article DOI: 10.1146/annurev.pharmtox.37.1.205 BindingDB Entry DOI: 10.7270/Q2M043ZH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(RAT) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development, Beerse
Curated by PDSP Ki Database
| |
Mol Pharmacol 63: 1082-93 (2003)
Article DOI: 10.1124/mol.63.5.1082 BindingDB Entry DOI: 10.7270/Q2BV7F62 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Agonist potency against cloned Metabotropic glutamate receptor 2 (mGluR-2). |
J Med Chem 43: 2609-45 (2000)
BindingDB Entry DOI: 10.7270/Q2DZ090Q |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Agonist potency against cloned human metabotropic glutamate receptor 1 |
J Med Chem 43: 2609-45 (2000)
BindingDB Entry DOI: 10.7270/Q2DZ090Q |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4 (mGluR4)
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4) |
J Med Chem 43: 2609-45 (2000)
BindingDB Entry DOI: 10.7270/Q2DZ090Q |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| Article
| n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells. |
Bioorg Med Chem Lett 6: 763-766 (1996)
Article DOI: 10.1016/0960-894X(96)00104-7 BindingDB Entry DOI: 10.7270/Q2WS8T7Q |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description Ability to inhibit mGluR1-alpha-mediated PI (phospho inosotol) hydrolysis was determined at BHK cells at 100 Micro M Concentration |
J Med Chem 38: 3717-9 (1995)
BindingDB Entry DOI: 10.7270/Q2V123TG |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description Ability to inhibit mGluR2-alpha induced cAMP formation was determined at BHK cells at 100 Micro M Concentration |
J Med Chem 38: 3717-9 (1995)
BindingDB Entry DOI: 10.7270/Q2V123TG |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4 (mGluR4)
(Homo sapiens (Human)) | BDBM50030628
((S)-4C3HPG | 4-(Amino-carboxy-methyl)-2-hydroxy-be...)Show InChI InChI=1S/C9H9NO5/c10-7(9(14)15)4-1-2-5(8(12)13)6(11)3-4/h1-3,7,11H,10H2,(H,12,13)(H,14,15) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Perugia
Curated by ChEMBL
| Assay Description Ability to inhibit mGluR4-alpha induced cAMP formation was determined at BHK cells at 100 Micro M Concentration |
J Med Chem 38: 3717-9 (1995)
BindingDB Entry DOI: 10.7270/Q2V123TG |
More data for this Ligand-Target Pair | |