Found 4 hits for monomerid = 50030876 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50030876
(CHEMBL3356123)Show SMILES Oc1ccc(NC(=O)[C@@H]2CCN(CC(=O)N3CCN(CC3)c3ccc(cc3)-c3ccoc3)C2)cc1Cl |r| Show InChI InChI=1S/C27H29ClN4O4/c28-24-15-22(3-6-25(24)33)29-27(35)20-7-9-30(16-20)17-26(34)32-12-10-31(11-13-32)23-4-1-19(2-5-23)21-8-14-36-18-21/h1-6,8,14-15,18,20,33H,7,9-13,16-17H2,(H,29,35)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylated ERK2 (unknown origin) by temperature dependent fluorescence (TdF) assay |
J Med Chem 57: 8817-26 (2014)
Article DOI: 10.1021/jm500847m
BindingDB Entry DOI: 10.7270/Q2Q52R6D |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50030876
(CHEMBL3356123)Show SMILES Oc1ccc(NC(=O)[C@@H]2CCN(CC(=O)N3CCN(CC3)c3ccc(cc3)-c3ccoc3)C2)cc1Cl |r| Show InChI InChI=1S/C27H29ClN4O4/c28-24-15-22(3-6-25(24)33)29-27(35)20-7-9-30(16-20)17-26(34)32-12-10-31(11-13-32)23-4-1-19(2-5-23)21-8-14-36-18-21/h1-6,8,14-15,18,20,33H,7,9-13,16-17H2,(H,29,35)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of unphosphorylated ERK2 (unknown origin) by temperature dependent fluorescence (TdF) assay |
J Med Chem 57: 8817-26 (2014)
Article DOI: 10.1021/jm500847m
BindingDB Entry DOI: 10.7270/Q2Q52R6D |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50030876
(CHEMBL3356123)Show SMILES Oc1ccc(NC(=O)[C@@H]2CCN(CC(=O)N3CCN(CC3)c3ccc(cc3)-c3ccoc3)C2)cc1Cl |r| Show InChI InChI=1S/C27H29ClN4O4/c28-24-15-22(3-6-25(24)33)29-27(35)20-7-9-30(16-20)17-26(34)32-12-10-31(11-13-32)23-4-1-19(2-5-23)21-8-14-36-18-21/h1-6,8,14-15,18,20,33H,7,9-13,16-17H2,(H,29,35)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of activated ERK2 (unknown origin) using IMAP peptide substrate after 30 mins by activated ERK2 assay |
J Med Chem 57: 8817-26 (2014)
Article DOI: 10.1021/jm500847m
BindingDB Entry DOI: 10.7270/Q2Q52R6D |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50030876
(CHEMBL3356123)Show SMILES Oc1ccc(NC(=O)[C@@H]2CCN(CC(=O)N3CCN(CC3)c3ccc(cc3)-c3ccoc3)C2)cc1Cl |r| Show InChI InChI=1S/C27H29ClN4O4/c28-24-15-22(3-6-25(24)33)29-27(35)20-7-9-30(16-20)17-26(34)32-12-10-31(11-13-32)23-4-1-19(2-5-23)21-8-14-36-18-21/h1-6,8,14-15,18,20,33H,7,9-13,16-17H2,(H,29,35)/t20-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of inactive ERK2 (unknown origin) coupled with human MEK1 using IMAP peptide substrate after 30 mins by coupled ERK2 assay |
J Med Chem 57: 8817-26 (2014)
Article DOI: 10.1021/jm500847m
BindingDB Entry DOI: 10.7270/Q2Q52R6D |
More data for this
Ligand-Target Pair | |
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