BindingDB PrimarySearch

BDBM50030949 (2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol::CHEMBL124807

SMILES: Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(nc12)-c1cccs1

InChI Key: InChIKey=LMNBPJQPSDYDKY-GUSNPEKLSA-N

Data: 1 KI 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50030949
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens (Human))	BDBM50030949 ((2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Inhibition of Leishmania mexicana GAPDH(glyceraldehyde-3-phosphate dehydrogenase)				Bioorg Med Chem Lett 8: 3505-10 (1999) BindingDB Entry DOI: 10.7270/Q26Q1XR4
University of Washington Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens (Human))	BDBM50030949 ((2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of Leishmania mexicana				J Med Chem 37: 3605-13 (1994) BindingDB Entry DOI: 10.7270/Q26W9BQD
University of Washington Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens (Human))	BDBM50030949 ((2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Ghent Curated by ChEMBL					Assay Description TInhibition of glyceraldehyde-3-phosphate dehydrogenase in Leishmania mexicana				J Med Chem 38: 3838-49 (1995) BindingDB Entry DOI: 10.7270/Q2HT2PZ4
University of Ghent Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens (Human))	BDBM50030949 ((2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Tested for the inhibitory activity against Glycosomal glyceraldehyd 3-phosphate dehydrogenase (gGAPDH) of Trypanosoma brucei				J Med Chem 37: 3605-13 (1994) BindingDB Entry DOI: 10.7270/Q26W9BQD
University of Washington Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens (Human))	BDBM50030949 ((2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Ghent Curated by ChEMBL					Assay Description Inhibition of glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei				J Med Chem 38: 3838-49 (1995) BindingDB Entry DOI: 10.7270/Q2HT2PZ4
University of Ghent Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens (Human))	BDBM50030949 ((2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington Curated by ChEMBL					Assay Description Tested for the inhibitory activity against Glycosomal glyceraldehyde 3-phosphate dehydrogenase (gGAPDH) of human erythrocyte				J Med Chem 37: 3605-13 (1994) BindingDB Entry DOI: 10.7270/Q26W9BQD
University of Washington Curated by ChEMBL					More data for this Ligand-Target Pair
Glyceraldehyde-3-phosphate dehydrogenase (Homo sapiens (Human))	BDBM50030949 ((2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-y...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Ghent Curated by ChEMBL					Assay Description Inhibition of Glyceraldehyde-3-phosphate dehydrogenase in human erythrocytes.				J Med Chem 38: 3838-49 (1995) BindingDB Entry DOI: 10.7270/Q2HT2PZ4
University of Ghent Curated by ChEMBL					More data for this Ligand-Target Pair