BDBM50031442 1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-methylbutylcarbamoyl)butyl]-2-cyclopentyl-10-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)decanamide::Alpha-ketocarbonyl derivative::CHEMBL307387
SMILES: CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCN1C(=O)c2ccccc2C1=O)C1CCCC1)C=O
InChI Key: InChIKey=OOEXUWDNTCTJMI-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
20S proteasome (Homo sapiens (Human)) | BDBM50031442 (1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc. Curated by ChEMBL | Assay Description Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain | J Med Chem 38: 2276-7 (1995) Article DOI: 10.1021/jm00013a002 BindingDB Entry DOI: 10.7270/Q2V127JJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Chymotrypsin-like protease CTRL-1 (Homo sapiens (Human)) | BDBM50031442 (1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for inhibition of chymotrypsin-like protease of proteasome from postmortem human liver and brain | Bioorg Med Chem Lett 6: 287-290 (1996) Article DOI: 10.1016/0960-894X(96)00014-5 BindingDB Entry DOI: 10.7270/Q2JQ1112 | |||||||||||
More data for this Ligand-Target Pair |