BDBM50031481 (2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol::2(R),5(R)-bis(hydroxymethyl)-3(R),4(R)-dihydroxypyrrolidine::2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine::CHEMBL312653
SMILES: OC[C@H]1N[C@H](CO)[C@@H](O)[C@@H]1O
InChI Key: InChIKey=PFYHYHZGDNWFIF-KVTDHHQDSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of rat isomaltase | Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-mannosidase 2C1 (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of soluble Alpha-mannosidase II in rat liver | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactase-glycosylceramidase (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maltase-glucoamylase (Homo sapiens (Human)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltase | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trehalase (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 3.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Wistar rat intestinal maltase | J Nat Prod 61: 625-8 (1998) Article DOI: 10.1021/np9705726 BindingDB Entry DOI: 10.7270/Q2F47NXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Wistar rat intestinal isomaltase | J Nat Prod 61: 625-8 (1998) Article DOI: 10.1021/np9705726 BindingDB Entry DOI: 10.7270/Q2F47NXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acidic alpha-glucosidase (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Wistar rat liver lysosomal alpha-glucosidase | J Nat Prod 61: 625-8 (1998) Article DOI: 10.1021/np9705726 BindingDB Entry DOI: 10.7270/Q2F47NXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lactase-glycosylceramidase (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Wistar rat intestinal lactase | J Nat Prod 61: 625-8 (1998) Article DOI: 10.1021/np9705726 BindingDB Entry DOI: 10.7270/Q2F47NXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mannosidase 2 alpha 1 (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of golgi Alpha-mannosidase II in rat liver | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mannosidase 2, alpha B1 (Rattus norvegicus) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | <5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of lysosomal Alpha-mannosidase II in rat liver | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-glucosidase MAL62 (Saccharomyces cerevisiae) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometrically | J Nat Prod 65: 198-202 (2002) BindingDB Entry DOI: 10.7270/Q2ZW1KN6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of rat intestinal maltase | Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of rat sucrase | Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycogen debranching enzyme (Homo sapiens (Human)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of amylo-1,6-glucosidase | Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat)) | BDBM50031481 ((2R,3R,4R,5R)-2,5-Bis-hydroxymethyl-pyrrolidine-3,...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University Curated by ChEMBL | Assay Description Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method | J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0 | |||||||||||
More data for this Ligand-Target Pair |