BindingDB PrimarySearch

BDBM50016703 2-Hydroxymethyl-pyrrolidine-3,4-diol::BDBM50031485::CHEMBL305131::CHEMBL80254::Imino-D-Arabinitol

SMILES: OC[C@H]1NC[C@@H](O)[C@@H]1O

InChI Key: InChIKey=OQEBIHBLFRADNM-ZZKAVYKESA-N

Data: 3 KI 22 IC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50016703
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glycogen phosphorylase, muscle form (Oryctolagus cuniculus (rabbit))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PDB PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Claude Bernard Lyon 1 Curated by ChEMBL					Assay Description Inhibition of rabbit muscle glycogen phosphorylase using tritium-labeled glycogen as substrate by scintillation counter				Eur J Med Chem 108: 444-54 (2016) BindingDB Entry DOI: 10.7270/Q2QR500M
Universit£ Claude Bernard Lyon 1 Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen Phosphorylase (PYGL) (Homo sapiens (Human))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against pig Liver glycogen phosphorylase a				J Med Chem 47: 3537-45 (2004) Article DOI: 10.1021/jm031121n BindingDB Entry DOI: 10.7270/Q2HM5977
Novo Nordisk A/S Curated by ChEMBL					More data for this Ligand-Target Pair
Mannosidase 2 alpha 1 (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Competitive Inhibitory activity against Golgi Alpha-mannosidase II				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Maltase-glucoamylase (Homo sapiens (Human))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Trehalase (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Mannosidase 2, alpha B1 (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of lysosomal Alpha-mannosidase II in rat liver				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Mannosidase 2 alpha 1 (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of golgi Alpha-mannosidase II in rat liver				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-mannosidase 2C1 (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	<5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of soluble Alpha-mannosidase II in rat liver				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-glucosidase MAL62 (Saccharomyces cerevisiae)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of yeast maltase alpha-glucosidase assessed as p-nitrophenol release by spectrophotometrically				J Nat Prod 65: 198-202 (2002) BindingDB Entry DOI: 10.7270/Q2ZW1KN6
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic alpha-glucosidase (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat intestinal maltase assessed as glucose release by Glucose B-test				J Nat Prod 65: 198-202 (2002) BindingDB Entry DOI: 10.7270/Q2ZW1KN6
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat intestinal sucrase assessed as glucose release by Glucose B-test				J Nat Prod 65: 198-202 (2002) BindingDB Entry DOI: 10.7270/Q2ZW1KN6
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat intestinal isomaltase assessed as glucose release by Glucose B-test				J Nat Prod 65: 198-202 (2002) BindingDB Entry DOI: 10.7270/Q2ZW1KN6
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Beta-mannosidase (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	2.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat epididymis beta-mannosidase assessed as p-nitrophenol release by spectrophotometrically				J Nat Prod 65: 198-202 (2002) BindingDB Entry DOI: 10.7270/Q2ZW1KN6
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Liver glycogen phosphorylase (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in basal glycogenolysis				Drug Metab Dispos 41: 878-87 (2013) Article DOI: 10.1124/dmd.112.050591 BindingDB Entry DOI: 10.7270/Q2TB18M8
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Liver glycogen phosphorylase (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of glycogen phosphorylase in rat hepatocytes assessed as reduction in glucagom-induced glycogenolysis				Drug Metab Dispos 41: 878-87 (2013) Article DOI: 10.1124/dmd.112.050591 BindingDB Entry DOI: 10.7270/Q2TB18M8
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-mannosidase 2C1 (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
CSIRO Division of Chemicals and Polymers Curated by ChEMBL					Assay Description Inhibitory activity against Mannosidase in jack bean (Canavalia ensiformis)				J Med Chem 32: 2084-9 (1989) BindingDB Entry DOI: 10.7270/Q2TQ6246
CSIRO Division of Chemicals and Polymers Curated by ChEMBL					More data for this Ligand-Target Pair
Glucoamylase, intracellular sporulation-specific (Saccharomyces cerevisiae S288c)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Haute-Alsace Curated by ChEMBL					Assay Description Inhibition of yeast alpha-D-glucosidase				Bioorg Med Chem 15: 4125-35 (2007) Article DOI: 10.1016/j.bmc.2007.03.073 BindingDB Entry DOI: 10.7270/Q2348M5N
Universit£ de Haute-Alsace Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat intestinal maltase				Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat sucrase				Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of rat isomaltase				Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen debranching enzyme (Homo sapiens (Human))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of amylo-1,6-glucosidase				Bioorg Med Chem 16: 2734-40 (2008) Article DOI: 10.1016/j.bmc.2008.01.032 BindingDB Entry DOI: 10.7270/Q2FB53T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Lactase-glycosylceramidase (Rattus norvegicus)	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of Glycosidases (lactase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen debranching enzyme (Homo sapiens (Human))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of amylo-1,6-glucosidase				Bioorg Med Chem 16: 7330-6 (2008) Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair
alpha-Glucosidase (α-Glucosidase) (Rattus norvegicus (Rat))	BDBM50016703 (2-Hydroxymethyl-pyrrolidine-3,4-diol \| BDBM5003148...) Show SMILES OC[C@H]1NC[C@@H](O)[C@@H]1O \|r\| Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hokuriku University Curated by ChEMBL					Assay Description Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method				J Med Chem 38: 2349-56 (1995) BindingDB Entry DOI: 10.7270/Q2N878T0
Hokuriku University Curated by ChEMBL					More data for this Ligand-Target Pair