BindingDB PrimarySearch

BDBM50031709 4-Guanidino-benzoic acid 4-carboxymethyl-phenyl ester; compound with methanesulfonic acid::CHEMBL433135

SMILES: [#7]\[#6](-[#7])=[#7]/c1ccc(cc1)-[#6](=O)-[#8]-c1ccc(-[#6]-[#6](-[#8])=O)cc1

InChI Key: InChIKey=XTKGXPFBKPYFDW-UHFFFAOYSA-N

Data: 8 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50031709
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kallikrein-1 (KLK1) (Homo sapiens (Human))	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Val-Leu-Arg-pNA) for pancreatic kallikrein in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Kallikrein-1 (KLK1) (Homo sapiens (Human))	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Pro-Phe-Arg-pNA) for plasma kallikrein in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Phe-Pip-Arg-pNA) thrombin in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Leukocyte elastase (Homo sapiens (Human))	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (MeO-Suc-Ala-Ala-Pro-Val-pNA) for sputum elastase in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-chymotrypsin (Bos taurus (bovine))	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (Suc-Ala-Ala-Pro-Phe-pNA) for chymotrypsin in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Plasmin (Rattus norvegicus)	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.25E+4	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (H-D-Val-Leu-Lys-pNA) for plasmin in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Trypsin-1 (Homo sapiens (Human))	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (Boc-Phe-Ser-Arg-AMC) for trypsin in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin G (Homo sapiens (Human))	BDBM50031709 (4-Guanidino-benzoic acid 4-carboxymethyl-phenyl es...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Concentration required to inhibit enzymatic cleavage of the chromogenic substrate (MeO-Suc-Ala-Ala-Pro-Met-pNA) for cathepsin G in vitro.				J Med Chem 38: 2521-3 (1995) BindingDB Entry DOI: 10.7270/Q2MC8Z12
Minase Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair