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SMILES: COc1ccc(cc1)-c1cccc2nc(NS(=O)(=O)C3CC3)nn12

InChI Key: InChIKey=RTQNXNBUCKFMMB-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50031752   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))		BDBM50031752
PNG
(CHEMBL3352896)
Show SMILES COc1ccc(cc1)-c1cccc2nc(NS(=O)(=O)C3CC3)nn12
Show InChI InChI=1S/C16H16N4O3S/c1-23-12-7-5-11(6-8-12)14-3-2-4-15-17-16(18-20(14)15)19-24(21,22)13-9-10-13/h2-8,13H,9-10H2,1H3,(H,18,19)
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Article
PubMed
n/an/a 5.74E+3n/an/an/an/an/an/a



Galapagos NV

Curated by ChEMBL


Assay Description
Inhibition of human recombinant JAK1

J Med Chem 57: 9323-42 (2014)


Article DOI: 10.1021/jm501262q
BindingDB Entry DOI: 10.7270/Q2GH9KK6
More data for this
Ligand-Target Pair