BindingDB PrimarySearch

BDBM50031778 (R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl)succinamide::(R)-2-(4-Benzyloxy-butyl)-N*4*-hydroxy-N*1*-((S)-1-methylcarbamoyl-2-phenyl-ethyl)-succinamide::CHEMBL87229

SMILES: CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCOCc1ccccc1)CC(=O)NO

InChI Key: InChIKey=IYJLBIPCLHKYKU-YADHBBJMSA-N

Data: 12 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50031778
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neutrophil collagenase (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	<2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human Matrix metalloproteinase-8				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sterling Winthrop Pharmaceuticals Research Division Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase(HNC), MMP-8				J Med Chem 38: 2570-81 (1995) BindingDB Entry DOI: 10.7270/Q2GM86B5
					More data for this Ligand-Target Pair
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human Matrix metalloproteinase-9				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3				Bioorg Med Chem Lett 5: 343-348 (1995) Article DOI: 10.1016/0960-894X(95)00032-O BindingDB Entry DOI: 10.7270/Q2JH3M44
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sterling Winthrop Pharmaceuticals Research Division Curated by ChEMBL					Assay Description Inhibitory potency against human stromelysin, MMP-3				J Med Chem 38: 2570-81 (1995) BindingDB Entry DOI: 10.7270/Q2GM86B5
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pomona College Curated by ChEMBL					Assay Description Inhibition of MMP3				Bioorg Med Chem 15: 2223-68 (2007) Article DOI: 10.1016/j.bmc.2007.01.011 BindingDB Entry DOI: 10.7270/Q2571DBD
Pomona College Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human neutrophil collagenase, matrix metalloproteinase-8				Bioorg Med Chem Lett 5: 343-348 (1995) Article DOI: 10.1016/0960-894X(95)00032-O BindingDB Entry DOI: 10.7270/Q2JH3M44
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	<100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human fibroblast stromelysin, matrix metalloprotease-3 (potent inhibitor)				Bioorg Med Chem Lett 5: 343-348 (1995) Article DOI: 10.1016/0960-894X(95)00032-O BindingDB Entry DOI: 10.7270/Q2JH3M44
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sterling Winthrop Pharmaceuticals Research Division Curated by ChEMBL					Assay Description Inhibitory potency against human fibroblast collagenase, MMP-1				J Med Chem 38: 2570-81 (1995) BindingDB Entry DOI: 10.7270/Q2GM86B5
					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human fibroblast collagenase, matrix metalloproteinase-1				Bioorg Med Chem Lett 5: 343-348 (1995) Article DOI: 10.1016/0960-894X(95)00032-O BindingDB Entry DOI: 10.7270/Q2JH3M44
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50031778 ((R)-2-(4-(benzyloxy)butyl)-N4-hydroxy-N1-((S)-1-(m...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human fibroblast collagenase, matrix metalloproteinase-1				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair