BDBM50031925 6-(4-Methyl-piperazin-1-yl)-7,8-dihydro-benzo[k]phenanthridine::CHEMBL417706

SMILES: CN1CCN(CC1)c1nc2ccccc2c-2c1CCc1ccccc-21

InChI Key: InChIKey=XZWNYGIFEAIRIB-UHFFFAOYSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50031925   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT)	BDBM50031925 (6-(4-Methyl-piperazin-1-yl)-7,8-dihydro-benzo[k]ph...) Show SMILES CN1CCN(CC1)c1nc2ccccc2c-2c1CCc1ccccc-21 Show InChI InChI=1S/C22H23N3/c1-24-12-14-25(15-13-24)22-19-11-10-16-6-2-3-7-17(16)21(19)18-8-4-5-9-20(18)23-22/h2-9H,10-15H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligand				J Med Chem 38: 2692-704 (1995) BindingDB Entry DOI: 10.7270/Q27H1K7H
					More data for this Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT)	BDBM50031925 (6-(4-Methyl-piperazin-1-yl)-7,8-dihydro-benzo[k]ph...) Show SMILES CN1CCN(CC1)c1nc2ccccc2c-2c1CCc1ccccc-21 Show InChI InChI=1S/C22H23N3/c1-24-12-14-25(15-13-24)22-19-11-10-16-6-2-3-7-17(16)21(19)18-8-4-5-9-20(18)23-22/h2-9H,10-15H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Rat 5-hydroxytryptamine 3 receptor (5-HT3) antagonist				J Med Chem 41: 2029-39 (1998) Article DOI: 10.1021/jm970745o BindingDB Entry DOI: 10.7270/Q2CJ8H7X
					More data for this Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor (Rattus norvegicus-RAT)	BDBM50031925 (6-(4-Methyl-piperazin-1-yl)-7,8-dihydro-benzo[k]ph...) Show SMILES CN1CCN(CC1)c1nc2ccccc2c-2c1CCc1ccccc-21 Show InChI InChI=1S/C22H23N3/c1-24-12-14-25(15-13-24)22-19-11-10-16-6-2-3-7-17(16)21(19)18-8-4-5-9-20(18)23-22/h2-9H,10-15H2,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Inhibition of [3H]granisetron binding to 5-hydroxytryptamine 3 receptor (5-HT 3 receptor) of rat cortex and hippocampus tissue				J Med Chem 42: 1556-75 (1999) Article DOI: 10.1021/jm981112s BindingDB Entry DOI: 10.7270/Q2D50NPW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Rattus norvegicus (rat))	BDBM50031925 (6-(4-Methyl-piperazin-1-yl)-7,8-dihydro-benzo[k]ph...) Show SMILES CN1CCN(CC1)c1nc2ccccc2c-2c1CCc1ccccc-21 Show InChI InChI=1S/C22H23N3/c1-24-12-14-25(15-13-24)22-19-11-10-16-6-2-3-7-17(16)21(19)18-8-4-5-9-20(18)23-22/h2-9H,10-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description Binding affinity to 5-hydroxytryptamine 2A receptor from rat cortex assayed using [3H]ketanserin as radioligand.				J Med Chem 38: 2692-704 (1995) BindingDB Entry DOI: 10.7270/Q27H1K7H
					More data for this Ligand-Target Pair
HTR4 (GUINEA PIG)	BDBM50031925 (6-(4-Methyl-piperazin-1-yl)-7,8-dihydro-benzo[k]ph...) Show SMILES CN1CCN(CC1)c1nc2ccccc2c-2c1CCc1ccccc-21 Show InChI InChI=1S/C22H23N3/c1-24-12-14-25(15-13-24)22-19-11-10-16-6-2-3-7-17(16)21(19)18-8-4-5-9-20(18)23-22/h2-9H,10-15H2,1H3	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description The compound was tested for its binding affinity towards 5-hydroxytryptamine 2A receptor from rat cortex using [3H]ketanserin as radioligand.				J Med Chem 38: 2692-704 (1995) BindingDB Entry DOI: 10.7270/Q27H1K7H
					More data for this Ligand-Target Pair
Serotonin receptor 2a and 2c (5HT2A and 5HT2C) (Rattus norvegicus (Rat))	BDBM50031925 (6-(4-Methyl-piperazin-1-yl)-7,8-dihydro-benzo[k]ph...) Show SMILES CN1CCN(CC1)c1nc2ccccc2c-2c1CCc1ccccc-21 Show InChI InChI=1S/C22H23N3/c1-24-12-14-25(15-13-24)22-19-11-10-16-6-2-3-7-17(16)21(19)18-8-4-5-9-20(18)23-22/h2-9H,10-15H2,1H3	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Siena Curated by ChEMBL					Assay Description The compound was tested for their binding affinity towards 5-hydroxytryptamine 2C receptor				J Med Chem 38: 2692-704 (1995) BindingDB Entry DOI: 10.7270/Q27H1K7H
					More data for this Ligand-Target Pair