BDBM50032172 (S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propionylamino)-4-methyl-pentanoylamino]-N-((1S,2S)-1-{(1S,2S)-1-[(S)-1-carboxy-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-methyl-butylcarbamoyl}-2-methyl-butyl)-succinamic acid::CHEMBL328942
SMILES: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
InChI Key: InChIKey=XUMJJSAQQCTKAO-SRYIDKSASA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
EDNRB (Homo sapiens (Human)) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity against endothelin B receptor from rabbit renal vascular smooth muscles | J Med Chem 38: 2809-19 (1995) BindingDB Entry DOI: 10.7270/Q2KD1WZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells | J Med Chem 38: 2809-19 (1995) BindingDB Entry DOI: 10.7270/Q2KD1WZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenylate cyclase (Homo sapiens (Human)) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a |
University of Arizona Curated by ChEMBL | Assay Description pA2 value was calculated from dose-response plots generated by using different concentrations ranging between 1 and 10 uM antagonist. | J Med Chem 39: 2449-55 (1996) Article DOI: 10.1021/jm960130b BindingDB Entry DOI: 10.7270/Q2JH3MT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucagon receptor (Rattus norvegicus) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona Curated by ChEMBL | Assay Description Inhibition of [125I]glucagon binding towards Glucagon receptor | J Med Chem 39: 2449-55 (1996) Article DOI: 10.1021/jm960130b BindingDB Entry DOI: 10.7270/Q2JH3MT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity against endothelin A receptor from rabbit renal vascular smooth muscles | J Med Chem 38: 2809-19 (1995) BindingDB Entry DOI: 10.7270/Q2KD1WZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRB (RAT) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibitory concentration was evaluated by measuring the binding affinity at the Endothelin B receptor in rat cerebellar membranes | J Med Chem 40: 2228-40 (1997) Article DOI: 10.1021/jm970161m BindingDB Entry DOI: 10.7270/Q24T6K1W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRB (RAT) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of ET-1 stimulated arachidonic acid release in CHO cells expressing rat ET- B receptors | J Med Chem 38: 2809-19 (1995) BindingDB Entry DOI: 10.7270/Q2KD1WZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells | J Med Chem 35: 3301-3 (1992) BindingDB Entry DOI: 10.7270/Q21C1XGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRB (RAT) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of ET-1 binding to Endothelin B receptor in cultured rat cerebellar membranes | J Med Chem 35: 3301-3 (1992) BindingDB Entry DOI: 10.7270/Q21C1XGJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucagon receptor (Rattus norvegicus) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona Curated by ChEMBL | Assay Description Inhibition of [125I]glucagon binding towards Glucagon receptor | J Med Chem 39: 2449-55 (1996) Article DOI: 10.1021/jm960130b BindingDB Entry DOI: 10.7270/Q2JH3MT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelin-1 receptor (Homo sapiens (Human)) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells | J Med Chem 40: 2228-40 (1997) Article DOI: 10.1021/jm970161m BindingDB Entry DOI: 10.7270/Q24T6K1W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EDNRB (Homo sapiens (Human)) | BDBM50032172 ((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity measured in CHO cells stably transfected with the human endothelin B receptor | J Med Chem 38: 2809-19 (1995) BindingDB Entry DOI: 10.7270/Q2KD1WZQ | |||||||||||
More data for this Ligand-Target Pair |