BDBM50032672 4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid::CHEMBL107039
SMILES: Cc1cc2CCCC(C)(C)c2cc1C(=C)c1ccc(cc1)C(O)=O
InChI Key: InChIKey=CMBRTFQBQGEDHH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Ability to bind directly to Retinoic acid receptor RXR-alpha was evaluated in a competitive binding assay. | J Med Chem 38: 3146-55 (1995) BindingDB Entry DOI: 10.7270/Q2542MMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma (Mus musculus) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity to Retinoic acid receptor RXR-gamma was evaluated in a competitive binding assay. | J Med Chem 38: 3146-55 (1995) BindingDB Entry DOI: 10.7270/Q2542MMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor beta (Mus musculus) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity to Retinoic acid receptor RXR-beta was determined in a competitive binding assay. | J Med Chem 38: 3146-55 (1995) BindingDB Entry DOI: 10.7270/Q2542MMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma (Mus musculus) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Ability to activate gene expression at Retinoic acid receptor RXR-gamma was evaluated in a cotransfection assay. | J Med Chem 38: 3146-55 (1995) BindingDB Entry DOI: 10.7270/Q2542MMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Ability to activate gene expression at Retinoic acid receptor RXR-alpha was evaluated in a cotransfection assay. | J Med Chem 38: 3146-55 (1995) BindingDB Entry DOI: 10.7270/Q2542MMT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor gamma/retinoic acid receptor alpha (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Queens , New York 11439 , United States. Curated by ChEMBL | Assay Description Agonist activity at RXRgamma (unknown origin) | J Med Chem 61: 2166-2210 (2018) Article DOI: 10.1021/acs.jmedchem.7b00315 BindingDB Entry DOI: 10.7270/Q2B56N68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Queens , New York 11439 , United States. Curated by ChEMBL | Assay Description Agonist activity at RXRaplha (unknown origin) | J Med Chem 61: 2166-2210 (2018) Article DOI: 10.1021/acs.jmedchem.7b00315 BindingDB Entry DOI: 10.7270/Q2B56N68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha/Retinoic acid receptor beta (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Queens , New York 11439 , United States. Curated by ChEMBL | Assay Description Agonist activity at RARbeta (unknown origin) | J Med Chem 61: 2166-2210 (2018) Article DOI: 10.1021/acs.jmedchem.7b00315 BindingDB Entry DOI: 10.7270/Q2B56N68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid receptor (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Queens , New York 11439 , United States. Curated by ChEMBL | Assay Description Agonist activity at RXRbeta (unknown origin) | J Med Chem 61: 2166-2210 (2018) Article DOI: 10.1021/acs.jmedchem.7b00315 BindingDB Entry DOI: 10.7270/Q2B56N68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor alpha/Retinoid X receptor alpha (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Queens , New York 11439 , United States. Curated by ChEMBL | Assay Description Agonist activity at RARaplha (unknown origin) | J Med Chem 61: 2166-2210 (2018) Article DOI: 10.1021/acs.jmedchem.7b00315 BindingDB Entry DOI: 10.7270/Q2B56N68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoic acid receptor RXR-alpha/gamma (Homo sapiens (Human)) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences , St. John's University , Queens , New York 11439 , United States. Curated by ChEMBL | Assay Description Agonist activity at RARgamma (unknown origin) | J Med Chem 61: 2166-2210 (2018) Article DOI: 10.1021/acs.jmedchem.7b00315 BindingDB Entry DOI: 10.7270/Q2B56N68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid X receptor beta (Mus musculus) | BDBM50032672 (4-[1-(3,8,8-Trimethyl-5,6,7,8-tetrahydro-naphthale...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
Ligand Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Ability to activate gene expression at Retinoic acid receptor RXR-beta was evaluated in a cotransfection assay. | J Med Chem 38: 3146-55 (1995) BindingDB Entry DOI: 10.7270/Q2542MMT | |||||||||||
More data for this Ligand-Target Pair |