null
SMILES: Nc1nc2n(COCCOP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
InChI Key: InChIKey=STXXGSWOWSSPRV-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA) | J Med Chem 38: 1005-14 (1995) BindingDB Entry DOI: 10.7270/Q2FF3RDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride | J Med Chem 38: 1005-14 (1995) BindingDB Entry DOI: 10.7270/Q2FF3RDR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4 | J Med Chem 36: 3771-83 (1994) BindingDB Entry DOI: 10.7270/Q23J3DKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes. | J Med Chem 39: 949-56 (1996) Article DOI: 10.1021/jm950736k BindingDB Entry DOI: 10.7270/Q2SN082H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Binding affinity against hydrophobic pocket of Purine nucleoside Phosphorylase | J Med Chem 36: 3771-83 (1994) BindingDB Entry DOI: 10.7270/Q23J3DKS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay | J Med Chem 36: 3455-63 (1993) BindingDB Entry DOI: 10.7270/Q2PR7V1V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Purine nucleoside phosphorylase (Homo sapiens (Human)) | BDBM50033666 (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
BioCryst Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4 | J Med Chem 36: 3771-83 (1994) BindingDB Entry DOI: 10.7270/Q23J3DKS | |||||||||||
More data for this Ligand-Target Pair |