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BDBM50033975 1-{5-[4,5-Bis-(3-methoxy-phenyl)-1H-imidazol-2-ylsulfanyl]-pentyl}-3-(2,4-difluoro-phenyl)-1-heptyl-urea::CHEMBL273824

SMILES: CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1cccc(OC)c1)-c1cccc(OC)c1)C(=O)Nc1ccc(F)cc1F

InChI Key: InChIKey=PFMVYRIXRRFDAS-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50033975   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sterol O-acyltransferase, Soat


(Rattus norvegicus)		BDBM50033975
PNG
(1-{5-[4,5-Bis-(3-methoxy-phenyl)-1H-imidazol-2-yls...)
Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1cccc(OC)c1)-c1cccc(OC)c1)C(=O)Nc1ccc(F)cc1F
Show InChI InChI=1S/C36H44F2N4O3S/c1-4-5-6-7-9-20-42(36(43)39-32-19-18-28(37)25-31(32)38)21-10-8-11-22-46-35-40-33(26-14-12-16-29(23-26)44-2)34(41-35)27-15-13-17-30(24-27)45-3/h12-19,23-25H,4-11,20-22H2,1-3H3,(H,39,43)(H,40,41)
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KEGG

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PC cid
PC sid
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PubMed
n/an/a 40n/an/an/an/an/an/a



DuPont Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% activity of Acyl coenzyme A:cholesterol acyltransferase 1 in vitro using rat liver microsome.

J Med Chem 38: 1067-83 (1995)


BindingDB Entry DOI: 10.7270/Q28S4P0T
More data for this
Ligand-Target Pair