BDBM50034417 4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamide::4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide::CHEMBL286737::US9320734, 100

SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1nncs1

InChI Key: InChIKey=ATEAASNFYTUARU-UHFFFAOYSA-N

Data: 2 KI  5 IC50  3 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50034417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Mus musculus)	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Displacement of biotinylated phosphatidylinositol-3,4,5-phosphate from mouse AKT1 PH domain by surface plasmon resonance competitive binding assay				Bioorg Med Chem 19: 2046-54 (2011) Article DOI: 10.1016/j.bmc.2011.01.049 BindingDB Entry DOI: 10.7270/Q2TQ61TR
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair
Endothelin-1 receptor (RAT)	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.				J Med Chem 38: 1344-54 (1995) BindingDB Entry DOI: 10.7270/Q20864BS
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a
The University of Texas Curated by ChEMBL					Assay Description Inhibition of pleckstrin homology domain of AKT by surface plasmon resonance spectroscopy				Bioorg Med Chem 17: 6983-92 (2009) Article DOI: 10.1016/j.bmc.2009.08.022 BindingDB Entry DOI: 10.7270/Q2513Z8T
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas Curated by ChEMBL					Assay Description Inhibition of Akt phosphorylation in human BxPC3 cells by Western blotting				Bioorg Med Chem 17: 6983-92 (2009) Article DOI: 10.1016/j.bmc.2009.08.022 BindingDB Entry DOI: 10.7270/Q2513Z8T
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	n/a	1.51E+4	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description SPR interaction analyses were performed with a Biacore 2000, using Biacore 2000 Control Software v3.2 and BIAevaluation v4.1 analysis software (Biaco...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description Inhibition of AKT was measured by Western blotting using specific antibodies against phospho-Ser473-AKT in MiaPaCa-2 cells.Inhibition of AKT was meas...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase [1-123] (Homo sapiens (Human))	BDBM50034417 (4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamid...) Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nncs1 Show InChI InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)	PDB GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System; Arizona Board of Regents on behalf of the University of Arizona US Patent					Assay Description Inhibition of AKT was measured by Western blots using specific antibodies against phospho-Ser473-AKT in HT-29 lung cancer cells. Inhibition of the ph...				US Patent US9320734 (2016) BindingDB Entry DOI: 10.7270/Q2QF8RRM
					More data for this Ligand-Target Pair