BDBM50034961 6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4-diamine::CHEMBL53912
SMILES: Nc1nc(Cl)cc(Nc2ccc(Cl)c(Cl)c2)n1
InChI Key: InChIKey=IPNLIYUZWFQPKO-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human)) | BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA topoisomerase I by direct assay with activated DNA and 25 uM dNTPs including [3H]-dTTP | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase (alpha/delta/epsilon) (Homo sapiens (Human)) | BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA polymerase by direct assay with activated DNA and 25 uM dNTPs lacking the expected competitor substrate | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA helicase/primase complex protein (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair |