BDBM50034993 (S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-imidazol-1-yl)-butyl]-phenyl}-acetylamino)-propionylamino]-hexanoic acid (2-cyclohexyl-ethyl)-amide::CHEMBL6269::SC-58272::[CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL]PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE
SMILES: Cc1nccn1CCCCc1ccc(CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC2CCCCC2)cc1
InChI Key: InChIKey=WHLPIOSHBKQGHA-KYJUHHDHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 0.0310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Co. Curated by ChEMBL | Assay Description Apparent binding affinity against Candida albicans N-Myristoyltransferase (NMT). | J Med Chem 38: 1837-40 (1995) Article DOI: 10.1021/jm00011a001 BindingDB Entry DOI: 10.7270/Q23J3GPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) (Candida albicans (Yeast)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle and Company Curated by ChEMBL | Assay Description The Compound was tested for the inhibition potency against C. albicans N-myristoyltransferase (NMT) and reported as apparent Ki | J Med Chem 41: 996-1000 (1998) Article DOI: 10.1021/jm980001q BindingDB Entry DOI: 10.7270/Q27080KF | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | >1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center Curated by ChEMBL | Assay Description Inhibitory activity against human N-myristoyltransferase (HsNmt) | Bioorg Med Chem Lett 11: 1833-7 (2001) BindingDB Entry DOI: 10.7270/Q2KS6TRW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glycylpeptide N-tetradecanoyltransferase (Saccharomyces cerevisiae) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of Saccharomyces cerevisiae NMT | J Biol Chem 282: 22185-94 (2007) Article DOI: 10.1074/jbc.M702696200 BindingDB Entry DOI: 10.7270/Q24Q7VWR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Inhibition of Candida albicans N-myristoyltransferase (NMT) with peptide GNAASARR-NH2 and [3H]myristoyl-CoA at 1 uM | Citation and Details BindingDB Entry DOI: 10.7270/Q2FJ2JXN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Company Curated by ChEMBL | Assay Description Inhibition activity against N-myristoyltransferase (NMT) of candida albicans. | J Med Chem 40: 2609-25 (1997) Article DOI: 10.1021/jm970094w BindingDB Entry DOI: 10.7270/Q2BR8VXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Company Curated by ChEMBL | Assay Description Inhibition activity against N-myristoyltransferase (NMT) of human. | J Med Chem 40: 2609-25 (1997) Article DOI: 10.1021/jm970094w BindingDB Entry DOI: 10.7270/Q2BR8VXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Co. Curated by ChEMBL | Assay Description Inhibitory activity against human N-Myristoyltransferase (NMT). | J Med Chem 38: 1837-40 (1995) Article DOI: 10.1021/jm00011a001 BindingDB Entry DOI: 10.7270/Q23J3GPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
G.D. Searle and Co. Curated by ChEMBL | Assay Description Inhibitory activity against Candida albicans N-Myristoyltransferase (NMT). | J Med Chem 38: 1837-40 (1995) Article DOI: 10.1021/jm00011a001 BindingDB Entry DOI: 10.7270/Q23J3GPZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
Nippon Roche Research Center Curated by ChEMBL | Assay Description Inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) | Bioorg Med Chem Lett 11: 1833-7 (2001) BindingDB Entry DOI: 10.7270/Q2KS6TRW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its inhibitory activity against Candida albicans N-Myristoyltransferase (NMT) | Bioorg Med Chem Lett 6: 1977-1982 (1996) Article DOI: 10.1016/0960-894X(96)00354-X BindingDB Entry DOI: 10.7270/Q2TH8MPP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peptide N-myristoyltransferase (Homo sapiens (Human)) | BDBM50034993 ((S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | n/a | n/a | 1.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Assay Description Tested for Inhibitory concentration against human N-myristoyltransferase (NMT) in radiochemical HPLC end point assay with peptide GNAASARR-NH2 and [3... | Citation and Details BindingDB Entry DOI: 10.7270/Q2FJ2JXN | |||||||||||
More data for this Ligand-Target Pair |