BDBM50035176 8-M-ADOT::CHEMBL53015::N-(8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-acetamide
SMILES: COc1cccc2CCC(Cc12)NC(C)=O
InChI Key: InChIKey=VDJCYVYVTWEIPD-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Melatonin receptor (Homo sapiens (Human)) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin (RABBIT) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 20.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor (Gallus gallus-Chick) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Groningen Curated by ChEMBL | Assay Description Binding affinity to compete for 2-[125I]iodomelatonin binding to chicken retinal membranes | J Med Chem 36: 2891-8 (1993) Article DOI: 10.1021/jm00072a008 BindingDB Entry DOI: 10.7270/Q2HT2RJK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1C (Gallus gallus) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Binding affinity towards melatonin receptor in chicken brain. | J Med Chem 39: 1797-805 (1996) Article DOI: 10.1021/jm9508189 BindingDB Entry DOI: 10.7270/Q29026HC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor (Homo sapiens (Human)) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 46.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Northwestern University Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 355: 365-75 (1997) Article DOI: 10.1007/pl00004956 BindingDB Entry DOI: 10.7270/Q2416VKF | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin (Chick) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 161 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Paris-Sud Curated by ChEMBL | Assay Description Binding affinity measured against Chicken brain melatonin receptor by using 2-[125I]-iodomelatonin as radioligand | Bioorg Med Chem Lett 8: 3325-30 (1999) BindingDB Entry DOI: 10.7270/Q2R78DD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1C (Gallus gallus) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 161 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description In vitro binding affinity against melatonin receptor using 2-[125I]iodomelatonin (0.05 nM) and chicken brain membranes | J Med Chem 39: 3089-95 (1996) Article DOI: 10.1021/jm960219h BindingDB Entry DOI: 10.7270/Q2736TNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1C (Gallus gallus) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 204 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Paris-Sud Curated by ChEMBL | Assay Description Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatonin as radioligand | J Med Chem 40: 739-48 (1997) Article DOI: 10.1021/jm960680+ BindingDB Entry DOI: 10.7270/Q2WQ06H4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1C (Gallus gallus) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 206 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS-BIOCIS Curated by ChEMBL | Assay Description Competitive binding by the displacement of 2-[125I]- Iodomelatonin binding from melatonin receptors in chicken brain membranes | J Med Chem 38: 2050-60 (1995) Article DOI: 10.1021/jm00012a004 BindingDB Entry DOI: 10.7270/Q2ZS307H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor (Homo sapiens (Human)) | BDBM50035176 (8-M-ADOT | CHEMBL53015 | N-(8-Methoxy-1,2,3,4-tetr...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Groningen Curated by ChEMBL | Assay Description Inhibition of 2-[125I]iodomelatonin stimulated calcium dependent dopamine release from the rabbit retina. | J Med Chem 36: 2891-8 (1993) Article DOI: 10.1021/jm00072a008 BindingDB Entry DOI: 10.7270/Q2HT2RJK | |||||||||||
More data for this Ligand-Target Pair |