BindingDB PrimarySearch

BDBM50035218 CHEMBL61::PODOFILOX::Podophyllinic acid lactone::Podophyllotoxin (PTOX)::podophyllotoxin

SMILES: COc1cc(cc(OC)c1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)c2cc3OCOc3cc12

InChI Key: InChIKey=YJGVMLPVUAXIQN-XVVDYKMHSA-N

Data: 1 KI 38 IC50 6 Kd 1 ITC

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 50035218
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	2.18E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity against tubulin using [3H]colchicine as radioligand				J Med Chem 23: 546-9 (1980) BindingDB Entry DOI: 10.7270/Q2XK8HRZ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Westphalian Wilhelms-University Curated by ChEMBL					Assay Description Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry analysis				Bioorg Med Chem 19: 4183-91 (2011) Article DOI: 10.1016/j.bmc.2011.06.010 BindingDB Entry DOI: 10.7270/Q2222XKG
Westphalian Wilhelms-University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin (Sus scrofa (Pig))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description In vitro activity assay using leishmania tarentolae and porcine brain tubulin.				Chem Biol Drug Des 72: 513-24 (2008) Article DOI: 10.1111/j.1747-0285.2008.00729.x BindingDB Entry DOI: 10.7270/Q2SQ8XWV
The Ohio State University					More data for this Ligand-Target Pair				3D Structure (crystal)
nuclear receptor subfamily 0 group B member 1 (Homo sapiens (Human))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	2.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay									PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q23777B0
					More data for this Ligand-Target Pair
nuclear receptor subfamily 0 group B member 1 (Homo sapiens (Human))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	>6.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay									PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q23777B0
					More data for this Ligand-Target Pair
Steroidogenic Factor 1 (Homo sapiens (Human))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	>6.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay									PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q2ZG6QV9
					More data for this Ligand-Target Pair
Steroidogenic Factor 1 (Homo sapiens (Human))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	>6.75E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay									PubChem Bioassay (2013) BindingDB Entry DOI: 10.7270/Q2ZG6QV9
					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine					Assay Description Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...				ACS Chem Biol 11: 3052-3060 (2016) Article DOI: 10.1021/acschembio.6b00560 BindingDB Entry DOI: 10.7270/Q23777JP
					More data for this Ligand-Target Pair
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine					Assay Description Each molecule was evaluated for its ability to inhibit purified mouse COX-2 or ovine COX-1 using a previously described assay. [Kalgutkar et al, J. M...				ACS Chem Biol 11: 3052-3060 (2016) Article DOI: 10.1021/acschembio.6b00560 BindingDB Entry DOI: 10.7270/Q23777JP
					More data for this Ligand-Target Pair
Tubulin (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
School of Pharmacy Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization				J Med Chem 37: 1126-35 (1994) BindingDB Entry DOI: 10.7270/Q2ZC81XN
School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill 27599 Curated by ChEMBL					Assay Description Inhibition of bovine tubulin polymerization				J Med Chem 40: 2266-75 (1997) Article DOI: 10.1021/jm960858s BindingDB Entry DOI: 10.7270/Q26M35ZF
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin (Sus scrofa (Pig))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization.(ITP)				J Med Chem 44: 3932-6 (2001) BindingDB Entry DOI: 10.7270/Q2PK0FFW
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin alpha chain /beta chain (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentration				J Med Chem 46: 1670-82 (2003) Article DOI: 10.1021/jm020292+ BindingDB Entry DOI: 10.7270/Q2HD7V1V
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
CSIR-Indian Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of bovine brain tubulin polymerization measured for 1 hr at 1 min intervals by fluorescence assay				Bioorg Med Chem Lett 24: 3356-60 (2014) Article DOI: 10.1016/j.bmcl.2014.05.096 BindingDB Entry DOI: 10.7270/Q2X068PJ
					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL					Assay Description Inhibition of bovine brain tubulin polymerization by fluorescence analysis				Bioorg Med Chem 22: 5466-75 (2014) Article DOI: 10.1016/j.bmc.2014.07.031 BindingDB Entry DOI: 10.7270/Q25D8TH0
					More data for this Ligand-Target Pair
Regulatory protein E2 (Human papillomavirus type 1a)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.41E+4	n/a	n/a	n/a	n/a	n/a
Tokyo University of Science Curated by ChEMBL					Assay Description Binding affinity to HPV1a recombinant E2 protein by surface plasmon resonance method				Bioorg Med Chem 16: 5815-25 (2008) Article DOI: 10.1016/j.bmc.2008.03.053 BindingDB Entry DOI: 10.7270/Q24B3136
Tokyo University of Science Curated by ChEMBL					More data for this Ligand-Target Pair
Regulatory protein E2 (Human papillomavirus type 1a)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a
Tokyo University of Science Curated by ChEMBL					Assay Description Binding affinity to HPV1a recombinant E2 protein activator domain by surface plasmon resonance assay				Bioorg Med Chem 16: 5815-25 (2008) Article DOI: 10.1016/j.bmc.2008.03.053 BindingDB Entry DOI: 10.7270/Q24B3136
Tokyo University of Science Curated by ChEMBL					More data for this Ligand-Target Pair
Regulatory protein E2 (Human papillomavirus type 1a)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a
Tokyo University of Science Curated by ChEMBL					Assay Description Binding affinity to HPV1a recombinant E2 protein hinge domain by surface plasmon resonance assay				Bioorg Med Chem 16: 5815-25 (2008) Article DOI: 10.1016/j.bmc.2008.03.053 BindingDB Entry DOI: 10.7270/Q24B3136
Tokyo University of Science Curated by ChEMBL					More data for this Ligand-Target Pair
Regulatory protein E2 (Human papillomavirus type 1a)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	>4.00E+5	n/a	n/a	n/a	n/a	n/a
Tokyo University of Science Curated by ChEMBL					Assay Description Binding affinity to HPV1a recombinant E2 protein DNA binding domain by surface plasmon resonance assay				Bioorg Med Chem 16: 5815-25 (2008) Article DOI: 10.1016/j.bmc.2008.03.053 BindingDB Entry DOI: 10.7270/Q24B3136
Tokyo University of Science Curated by ChEMBL					More data for this Ligand-Target Pair
Regulatory protein E2 (Human papillomavirus type 11)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	2.01E+4	n/a	n/a	n/a	n/a	n/a
Tokyo University of Science Curated by ChEMBL					Assay Description Binding affinity to HPV11 recombinant E2 protein by surface plasmon resonance method				Bioorg Med Chem 16: 5815-25 (2008) Article DOI: 10.1016/j.bmc.2008.03.053 BindingDB Entry DOI: 10.7270/Q24B3136
Tokyo University of Science Curated by ChEMBL					More data for this Ligand-Target Pair
Human papillomavirus regulatory protein E2 (Human papillomavirus type 16)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	7.05E+4	n/a	n/a	n/a	n/a	n/a
Tokyo University of Science Curated by ChEMBL					Assay Description Binding affinity to HPV16 recombinant E2 protein by surface plasmon resonance method				Bioorg Med Chem 16: 5815-25 (2008) Article DOI: 10.1016/j.bmc.2008.03.053 BindingDB Entry DOI: 10.7270/Q24B3136
Tokyo University of Science Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase) (Ovis aries (Sheep))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Inhibition of ovine COX1				Bioorg Med Chem Lett 20: 1787-91 (2010) Article DOI: 10.1016/j.bmcl.2010.01.009 BindingDB Entry DOI: 10.7270/Q2J966H5
Vanderbilt University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Inhibition of mouse COX2				Bioorg Med Chem Lett 20: 1787-91 (2010) Article DOI: 10.1016/j.bmcl.2010.01.009 BindingDB Entry DOI: 10.7270/Q2J966H5
Vanderbilt University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville campus) Curated by ChEMBL					Assay Description Inhibition of human glucocorticoid receptor				Antimicrob Agents Chemother 53: 2824-33 (2009) Article DOI: 10.1128/AAC.01568-08 BindingDB Entry DOI: 10.7270/Q2QV3MSN
Monash University (Parkville campus) Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Pharmaceutical Chemistry Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization				J Med Chem 36: 1146-56 (1993) BindingDB Entry DOI: 10.7270/Q2BV7H8S
Institute of Pharmaceutical Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In vitro inhibition of purified bovine brain tubulin polymerisation in the absence of microtubule-associated proteins.				Citation and Details BindingDB Entry DOI: 10.7270/Q2PK0J9B
TBA					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Ability to inhibit Tubulin polymerization in Bovine brain				J Med Chem 34: 2579-88 (1991) BindingDB Entry DOI: 10.7270/Q2KW5J8Z
Purdue University Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Westphalian Wilhelms-University Curated by ChEMBL					Assay Description In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees C				J Med Chem 46: 3382-94 (2003) Article DOI: 10.1021/jm0307685 BindingDB Entry DOI: 10.7270/Q2VT1VVK
Westphalian Wilhelms-University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization				J Med Chem 40: 3049-56 (1997) Article DOI: 10.1021/jm970146h BindingDB Entry DOI: 10.7270/Q2TQ648T
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Regensburg Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization using isolated calf brain				J Med Chem 40: 3524-33 (1997) Article DOI: 10.1021/jm970177c BindingDB Entry DOI: 10.7270/Q29S1TRH
Universit£t Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Concentration inhibiting tubulin polymerization (ITP)				J Med Chem 42: 4081-7 (1999) Article DOI: 10.1021/jm990208z BindingDB Entry DOI: 10.7270/Q2Z60RSS
					More data for this Ligand-Target Pair
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University Curated by ChEMBL					Assay Description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly				Bioorg Med Chem Lett 15: 5382-5 (2005) Article DOI: 10.1016/j.bmcl.2005.09.001 BindingDB Entry DOI: 10.7270/Q2Z322D9
The Ohio State University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of bovine tubulin polymerization				J Med Chem 37: 3400-7 (1994) Article DOI: 10.1021/jm00046a025 BindingDB Entry DOI: 10.7270/Q2HQ42MX
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Ferrara Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization in bovine brain by tubulin assembly assay				J Med Chem 49: 3906-15 (2006) Article DOI: 10.1021/jm060355e BindingDB Entry DOI: 10.7270/Q20004VG
Universit£ di Ferrara Curated by ChEMBL					More data for this Ligand-Target Pair
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Westphalian Wilhelms-University Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization in porcine brain				J Med Chem 49: 7816-25 (2006) Article DOI: 10.1021/jm0605031 BindingDB Entry DOI: 10.7270/Q28918ND
Westphalian Wilhelms-University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
China Medical College Curated by ChEMBL					Assay Description Inhibition of bovine tubulin polymerization				J Med Chem 43: 4479-87 (2000) Article DOI: 10.1021/jm000151c BindingDB Entry DOI: 10.7270/Q2JS9T53
China Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Similar to alpha-tubulin isoform 1 (Bos taurus)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of bovine brain tubulin polymerization (ITP).				J Med Chem 41: 1155-62 (1998) Article DOI: 10.1021/jm9707479 BindingDB Entry DOI: 10.7270/Q2RN3BKW
					More data for this Ligand-Target Pair
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Binding affinity to pig brain tubulin at 10 uM after 15 mins relative to control				Bioorg Med Chem 16: 7552-60 (2008) Article DOI: 10.1016/j.bmc.2008.07.039 BindingDB Entry DOI: 10.7270/Q2FN1909
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Westphalian Wilhelms-University Curated by ChEMBL					Assay Description Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry				Eur J Med Chem 45: 3420-38 (2010) Article DOI: 10.1016/j.ejmech.2010.04.032 BindingDB Entry DOI: 10.7270/Q2W95D13
Westphalian Wilhelms-University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Competitive binding affinity to pig brain tubulin colchicine binding site after 1 hr by mass spectrophotometric analysis in presence of colchicine				J Med Chem 56: 5562-86 (2013) Article DOI: 10.1021/jm400575x BindingDB Entry DOI: 10.7270/Q24B3477
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Westphalian Wilhelms-University Curated by ChEMBL					Assay Description Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetric assay				J Med Chem 52: 1284-94 (2009) Article DOI: 10.1021/jm801338r BindingDB Entry DOI: 10.7270/Q2VD7274
Westphalian Wilhelms-University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Westphalian Wilhelms-University Curated by ChEMBL					Assay Description Inhibition of pig tubulin polymerization determined after 45 mins at 37 degC by turbidimetric analysis				J Med Chem 54: 4247-63 (2011) Article DOI: 10.1021/jm200436t BindingDB Entry DOI: 10.7270/Q2BK1G7W
Westphalian Wilhelms-University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tubulin beta chain (Sus scrofa)	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
CancerCare Manitoba Curated by ChEMBL					Assay Description Inhibition of porcine brain tubulin polymerization				J Med Chem 50: 6059-66 (2007) Article DOI: 10.1021/jm0708984 BindingDB Entry DOI: 10.7270/Q20C4ZJP
CancerCare Manitoba Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Nuclear receptor ROR-alpha (Homo sapiens (Human))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q26Q1VNZ
					More data for this Ligand-Target Pair
Steroidogenic Factor 1 (Homo sapiens (Human))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	PCBioAssay	n/a	n/a	45.4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Molecular Screening Center Curated by PubChem BioAssay					Assay Description Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...				PubChem Bioassay (2007) BindingDB Entry DOI: 10.7270/Q2319T8T
					More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 50035218
Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
Tubulin (Bos taurus (Bovine))	BDBM50035218 (CHEMBL61 \| PODOFILOX \| Podophyllinic acid lactone ...)	GoogleScholar PDB	CHEBI KEGG PC cid PC sid PDB		-260	-74.6	-185	3.95	n/a	30
Huazhong Agricultural University		GoogleScholar PDB	CHEBI KEGG PC cid PC sid PDB		ACS Chem Biol 12: 746-752 (2017)