BDBM50035391 CHEMBL3343370

SMILES: COc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCCC5)c(OC)cc34)c(F)c2)c1C(F)(F)F

InChI Key: InChIKey=MCDUHIJCTCJBFK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50035391   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50035391 (CHEMBL3343370) Show SMILES COc1ccc(cc1)-n1nnc(C(=O)Nc2ccc(Oc3ccnc4cc(OCCCN5CCCC5)c(OC)cc34)c(F)c2)c1C(F)(F)F Show InChI InChI=1S/C34H32F4N6O5/c1-46-23-9-7-22(8-10-23)44-32(34(36,37)38)31(41-42-44)33(45)40-21-6-11-28(25(35)18-21)49-27-12-13-39-26-20-30(29(47-2)19-24(26)27)48-17-5-16-43-14-3-4-15-43/h6-13,18-20H,3-5,14-17H2,1-2H3,(H,40,45)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Curated by ChEMBL					Assay Description Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay				Bioorg Med Chem 22: 6438-52 (2014) Article DOI: 10.1016/j.bmc.2014.09.037 BindingDB Entry DOI: 10.7270/Q2BG2QM2
					More data for this Ligand-Target Pair