BDBM50035558 5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoquinoline::CHEMBL310238

SMILES: Fc1ccccc1C1=Cc2ccccc2C2=NCCN12

InChI Key: InChIKey=CRASKXTVWBAFRS-UHFFFAOYSA-N

Data: 2 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50035558   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Polycomb protein EED (EED) (Homo sapiens (Human))	BDBM50035558 (5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...) Show SMILES Fc1ccccc1C1=Cc2ccccc2C2=NCCN12 |t:8,17| Show InChI InChI=1S/C17H13FN2/c18-15-8-4-3-7-14(15)16-11-12-5-1-2-6-13(12)17-19-9-10-20(16)17/h1-8,11H,9-10H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of EED in human G401 cells assessed as reduction in global H3K27me3 level after 48 hrs by ELISA				J Med Chem 60: 2215-2226 (2017) Article DOI: 10.1021/acs.jmedchem.6b01576 BindingDB Entry DOI: 10.7270/Q20G3NDT
					More data for this Ligand-Target Pair				3D Structure (crystal)
Platelet activating factor receptor (Homo sapiens (Human))	BDBM50035558 (5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...) Show SMILES Fc1ccccc1C1=Cc2ccccc2C2=NCCN12 |t:8,17| Show InChI InChI=1S/C17H13FN2/c18-15-8-4-3-7-14(15)16-11-12-5-1-2-6-13(12)17-19-9-10-20(16)17/h1-8,11H,9-10H2	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sandoz Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-PAF binding to human platelet activating factor receptor				J Med Chem 38: 234-40 (1995) BindingDB Entry DOI: 10.7270/Q27M06Z1
					More data for this Ligand-Target Pair