BDBM50036129 14-chloromethyl-7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione::CHEMBL335455
SMILES: CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5OCOc5cc4c(CCl)c3Cn1c2=O
InChI Key: InChIKey=FGIXZILUSHAOJP-QFIPXVFZSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50036129 (14-chloromethyl-7-ethyl-7-hydroxy-(7S)-7,8,11,13-t...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute Curated by ChEMBL | Assay Description Inhibition of topoisomerase I activity was determined in vitro by using the cleavable complex assay(calf thymus) | J Med Chem 38: 395-401 (1995) BindingDB Entry DOI: 10.7270/Q2F47N67 | |||||||||||
More data for this Ligand-Target Pair |