BindingDB PrimarySearch

BDBM50037479 (6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL326103

SMILES: CCN1CC[C@@]2(C)[C@@H](C)C1Cc1ccc(O)cc21

InChI Key: InChIKey=ZMAYVLNGIHEQKO-RMZCCROUSA-N

Data: 5 KI 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50037479
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50037479 ((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membrane				J Med Chem 37: 3408-18 (1994) BindingDB Entry DOI: 10.7270/Q2M32WD4
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50037479 ((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membrane				J Med Chem 37: 3408-18 (1994) BindingDB Entry DOI: 10.7270/Q2M32WD4
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Mu-type opioid receptor (Rattus norvegicus (rat))	BDBM50037479 ((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellum				J Med Chem 37: 3408-18 (1994) BindingDB Entry DOI: 10.7270/Q2M32WD4
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Delta-type opioid receptor (Homo sapiens (Human))	BDBM50037479 ((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	158	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membrane				J Med Chem 37: 3408-18 (1994) BindingDB Entry DOI: 10.7270/Q2M32WD4
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50037479 ((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.66E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Virginia Commonwealth University Curated by ChEMBL					Assay Description Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellum				J Med Chem 37: 3408-18 (1994) BindingDB Entry DOI: 10.7270/Q2M32WD4
Virginia Commonwealth University Curated by ChEMBL					More data for this Ligand-Target Pair
Opioid receptors; mu/kappa/delta (Homo sapiens (Human))	BDBM50037479 ((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaCl				J Med Chem 23: 985-90 (1980) BindingDB Entry DOI: 10.7270/Q2HD7XT0
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Opioid receptors; mu/kappa/delta (Homo sapiens (Human))	BDBM50037479 ((6S,11R)-3-Ethyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Opioid receptors binding by inhibiting specific [3H]naloxone binding by 50% in the presence of 100 mM NaCl				J Med Chem 23: 985-90 (1980) BindingDB Entry DOI: 10.7270/Q2HD7XT0
TBA Curated by ChEMBL					More data for this Ligand-Target Pair