BDBM50037887 CHEMBL3358267

SMILES: COCc1cc(ccc1OC)C(=O)NC(Cc1ccc(cc1)-c1cccc(c1)C(C)C)C(=O)NCCN(C)C

InChI Key: InChIKey=YZGIYVNTXWDDDE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50037887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kinesin-like protein KIFC1 (Homo sapiens (Human))	BDBM50037887 (CHEMBL3358267) Show SMILES COCc1cc(ccc1OC)C(=O)NC(Cc1ccc(cc1)-c1cccc(c1)C(C)C)C(=O)NCCN(C)C Show InChI InChI=1S/C32H41N3O4/c1-22(2)25-8-7-9-26(19-25)24-12-10-23(11-13-24)18-29(32(37)33-16-17-35(3)4)34-31(36)27-14-15-30(39-6)28(20-27)21-38-5/h7-15,19-20,22,29H,16-18,21H2,1-6H3,(H,33,37)(H,34,36)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminal His6-tagged KIFC1 (Q305-K673 aa) (unknown origin) expressed in Escherichia coli BL21 (DE3) by malachite green as...				J Med Chem 57: 9958-70 (2014) Article DOI: 10.1021/jm501179r BindingDB Entry DOI: 10.7270/Q2QF8VG8
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