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BDBM50038766 3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carboxylic acid (3-benzoyl-phenyl)-amide::CHEMBL64449::RP 59227::RP 59228::RP-58467

SMILES: O=C(Nc1cccc(c1)C(=O)c1ccccc1)c1ccn2C(SCc12)c1cccnc1

InChI Key: InChIKey=PQQFNXGONTVQLM-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50038766   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50038766
PNG
(3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carboxy...)
Show SMILES O=C(Nc1cccc(c1)C(=O)c1ccccc1)c1ccn2C(SCc12)c1cccnc1
Show InChI InChI=1S/C25H19N3O2S/c29-23(17-6-2-1-3-7-17)18-8-4-10-20(14-18)27-24(30)21-11-13-28-22(21)16-31-25(28)19-9-5-12-26-15-19/h1-15,25H,16H2,(H,27,30)
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4.70n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50038766
PNG
(3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carboxy...)
Show SMILES O=C(Nc1cccc(c1)C(=O)c1ccccc1)c1ccn2C(SCc12)c1cccnc1
Show InChI InChI=1S/C25H19N3O2S/c29-23(17-6-2-1-3-7-17)18-8-4-10-20(14-18)27-24(30)21-11-13-28-22(21)16-31-25(28)19-9-5-12-26-15-19/h1-15,25H,16H2,(H,27,30)
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6.20n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Cavia porcellus)
BDBM50038766
PNG
(3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carboxy...)
Show SMILES O=C(Nc1cccc(c1)C(=O)c1ccccc1)c1ccn2C(SCc12)c1cccnc1
Show InChI InChI=1S/C25H19N3O2S/c29-23(17-6-2-1-3-7-17)18-8-4-10-20(14-18)27-24(30)21-11-13-28-22(21)16-31-25(28)19-9-5-12-26-15-19/h1-15,25H,16H2,(H,27,30)
MMDB

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32n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand


J Med Chem 37: 2011-32 (1994)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50038766
PNG
(3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carboxy...)
Show SMILES O=C(Nc1cccc(c1)C(=O)c1ccccc1)c1ccn2C(SCc12)c1cccnc1
Show InChI InChI=1S/C25H19N3O2S/c29-23(17-6-2-1-3-7-17)18-8-4-10-20(14-18)27-24(30)21-11-13-28-22(21)16-31-25(28)19-9-5-12-26-15-19/h1-15,25H,16H2,(H,27,30)
PDB

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869n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)

More data for this
Ligand-Target Pair
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50038766
PNG
(3-Pyridin-3-yl-1H-pyrrolo[1,2-c]thiazole-7-carboxy...)
Show SMILES O=C(Nc1cccc(c1)C(=O)c1ccccc1)c1ccn2C(SCc12)c1cccnc1
Show InChI InChI=1S/C25H19N3O2S/c29-23(17-6-2-1-3-7-17)18-8-4-10-20(14-18)27-24(30)21-11-13-28-22(21)16-31-25(28)19-9-5-12-26-15-19/h1-15,25H,16H2,(H,27,30)
PDB

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PubMed
1.36E+3n/an/an/an/an/an/an/an/a



Rhone-Poulenc Sante

Curated by PDSP Ki Database




J Pharmacol Exp Ther 252: 1221-7 (1990)

More data for this
Ligand-Target Pair