BDBM50038908 1-[4-(2-Chloro-phenyl)-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea::CHEMBL65347

SMILES: Fc1ccc(NC(=O)Nc2cnc3ccccc3c2-c2ccccc2Cl)c(F)c1

InChI Key: InChIKey=XAEZWDBLMMMZIT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038908   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM50038908 (1-[4-(2-Chloro-phenyl)-quinolin-3-yl]-3-(2,4-diflu...) Show SMILES Fc1ccc(NC(=O)Nc2cnc3ccccc3c2-c2ccccc2Cl)c(F)c1 |(8.52,-13.45,;8.52,-11.91,;7.17,-11.15,;7.17,-9.61,;8.5,-8.84,;8.49,-7.3,;7.15,-6.54,;7.15,-5,;5.82,-7.31,;4.49,-6.54,;4.48,-5,;3.13,-4.23,;1.82,-5.02,;.47,-4.25,;-.86,-5.02,;-.86,-6.56,;.49,-7.31,;1.82,-6.56,;3.16,-7.33,;3.16,-8.87,;4.5,-9.62,;4.49,-11.15,;3.16,-11.93,;1.82,-11.16,;1.82,-9.62,;.49,-8.85,;9.83,-9.6,;11.16,-8.8,;9.85,-11.13,)| Show InChI InChI=1S/C22H14ClF2N3O/c23-16-7-3-1-5-14(16)21-15-6-2-4-8-18(15)26-12-20(21)28-22(29)27-19-10-9-13(24)11-17(19)25/h1-12H,(H2,27,28,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes				J Med Chem 37: 2079-84 (1994) BindingDB Entry DOI: 10.7270/Q23F4NPC
					More data for this Ligand-Target Pair