BDBM50038912 1-[4-(2-Chloro-phenyl)-6-methyl-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea::CHEMBL62894

SMILES: Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1

InChI Key: InChIKey=KITCISNOGDGHMA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038912   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM50038912 (1-[4-(2-Chloro-phenyl)-6-methyl-quinolin-3-yl]-3-(...) Show SMILES Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1 |(-13.32,-5.89,;-11.98,-5.12,;-11.98,-3.57,;-10.68,-2.8,;-9.33,-3.57,;-8,-2.78,;-6.67,-3.55,;-6.67,-5.09,;-5.32,-5.86,;-3.99,-5.09,;-4.01,-3.55,;-2.65,-5.86,;-2.65,-7.4,;-3.98,-8.17,;-3.97,-9.71,;-2.63,-10.46,;-2.61,-12,;-1.3,-9.68,;-1.31,-8.15,;.02,-7.36,;-8,-5.88,;-8,-7.42,;-9.33,-8.17,;-9.33,-9.71,;-8,-10.48,;-6.65,-9.71,;-6.64,-8.17,;-5.1,-8.17,;-9.33,-5.11,;-10.66,-5.86,)| Show InChI InChI=1S/C23H16ClF2N3O/c1-13-6-8-19-16(10-13)22(15-4-2-3-5-17(15)24)21(12-27-19)29-23(30)28-20-9-7-14(25)11-18(20)26/h2-12H,1H3,(H2,28,29,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	16.8	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes				J Med Chem 37: 2079-84 (1994) BindingDB Entry DOI: 10.7270/Q23F4NPC
					More data for this Ligand-Target Pair