BDBM50038919 1-[4-(2-Chloro-phenyl)-6-ethyl-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea::CHEMBL63408

SMILES: CCc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1

InChI Key: InChIKey=FEQQVGCUWPILNG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sterol O-acyltransferase, Soat (Rattus norvegicus)	BDBM50038919 (1-[4-(2-Chloro-phenyl)-6-ethyl-quinolin-3-yl]-3-(2...) Show SMILES CCc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1 |(2.57,-2.46,;3.92,-3.23,;5.25,-2.45,;5.25,-.91,;6.58,-.12,;7.92,-.89,;9.24,-.12,;10.58,-.89,;10.58,-2.43,;11.92,-3.2,;13.25,-2.43,;13.24,-.89,;14.59,-3.18,;14.59,-4.72,;13.26,-5.49,;13.28,-7.03,;14.61,-7.8,;14.63,-9.34,;15.94,-7.01,;15.94,-5.48,;17.27,-4.7,;9.25,-3.2,;9.25,-4.74,;7.92,-5.51,;7.92,-7.05,;9.25,-7.82,;10.59,-7.03,;10.6,-5.51,;12.09,-5.91,;7.92,-2.43,;6.59,-3.2,)| Show InChI InChI=1S/C24H18ClF2N3O/c1-2-14-7-9-20-17(11-14)23(16-5-3-4-6-18(16)25)22(13-28-20)30-24(31)29-21-10-8-15(26)12-19(21)27/h3-13H,2H2,1H3,(H2,29,30,31)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries, Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against acyl coenzyme A:cholesterol acyltransferase in rat microsomes				J Med Chem 37: 2079-84 (1994) BindingDB Entry DOI: 10.7270/Q23F4NPC
					More data for this Ligand-Target Pair