new BindingDB logo
myBDB logout

BDBM50039082 6,7-Dimethoxy-3-thiophen-3-yl-quinoline::CHEMBL66643::RPR-101511

SMILES: COc1cc2cc(cnc2cc1OC)-c1ccsc1

InChI Key: InChIKey=KGGRQYJJHXVWSI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50039082   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50039082
PNG
(6,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccsc1
Show InChI InChI=1S/C15H13NO2S/c1-17-14-6-11-5-12(10-3-4-19-9-10)8-16-13(11)7-15(14)18-2/h3-9H,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 461n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3097-100 (2003)


BindingDB Entry DOI: 10.7270/Q2HH6JGM
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50039082
PNG
(6,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccsc1
Show InChI InChI=1S/C15H13NO2S/c1-17-14-6-11-5-12(10-3-4-19-9-10)8-16-13(11)7-15(14)18-2/h3-9H,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 461n/an/an/an/an/an/a



Aventis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor


Bioorg Med Chem Lett 13: 3091-5 (2003)


BindingDB Entry DOI: 10.7270/Q2N8796B
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50039082
PNG
(6,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccsc1
Show InChI InChI=1S/C15H13NO2S/c1-17-14-6-11-5-12(10-3-4-19-9-10)8-16-13(11)7-15(14)18-2/h3-9H,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a>2.00E+4n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Concentration required to inhibit phosphorylation of isolated human epidermal growth factor tyrosine kinase receptor by 50%


J Med Chem 37: 2129-37 (1994)


BindingDB Entry DOI: 10.7270/Q29Z93Z8
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50039082
PNG
(6,7-Dimethoxy-3-thiophen-3-yl-quinoline | CHEMBL66...)
Show SMILES COc1cc2cc(cnc2cc1OC)-c1ccsc1
Show InChI InChI=1S/C15H13NO2S/c1-17-14-6-11-5-12(10-3-4-19-9-10)8-16-13(11)7-15(14)18-2/h3-9H,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 20n/an/an/an/an/an/a



Rhône-Poulenc Rorer Central Research

Curated by ChEMBL


Assay Description
Inhibition of human PDGF receptor phosphorylation; 0.01-0.02


J Med Chem 37: 2129-37 (1994)


BindingDB Entry DOI: 10.7270/Q29Z93Z8
More data for this
Ligand-Target Pair