BDBM50040348 8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-purine-2,6-dione::BRL-61063::CHEMBL356323
SMILES: Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2[nH]1
InChI Key: InChIKey=KSPYMJJKQMWWNB-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50040348 (8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of cGMP hydrolysis by PDE 5A | J Med Chem 37: 476-85 (1994) BindingDB Entry DOI: 10.7270/Q2P26X6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human)) | BDBM50040348 (8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Glasgow Curated by ChEMBL | Assay Description Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assay | J Med Chem 54: 3331-47 (2011) Article DOI: 10.1021/jm200070e BindingDB Entry DOI: 10.7270/Q2CF9R75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Rattus norvegicus (rat)) | BDBM50040348 (8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of adenosine binding to A1 receptorof rat brain homogenates | J Med Chem 37: 476-85 (1994) BindingDB Entry DOI: 10.7270/Q2P26X6N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human)) | BDBM50040348 (8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 910 | n/a | n/a | n/a | n/a |
University of Glasgow Curated by ChEMBL | Assay Description Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into foci | J Med Chem 54: 3331-47 (2011) Article DOI: 10.1021/jm200070e BindingDB Entry DOI: 10.7270/Q2CF9R75 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50040348 (8-Amino-1,3-bis-cyclopropylmethyl-3,7-dihydro-puri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 7.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Curated by ChEMBL | Assay Description Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 microM. | J Med Chem 37: 476-85 (1994) BindingDB Entry DOI: 10.7270/Q2P26X6N | |||||||||||
More data for this Ligand-Target Pair |