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SMILES: CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O

InChI Key: InChIKey=OAXIYDWDKICQCU-PVHODMMVSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50040594   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interstitial collagenase


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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 5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase -1

Bioorg Med Chem Lett 6: 329-332 (1996)


Article DOI: 10.1016/0960-894X(96)00024-8
BindingDB Entry DOI: 10.7270/Q2S75GBB
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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 20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase -3

Bioorg Med Chem Lett 6: 329-332 (1996)


Article DOI: 10.1016/0960-894X(96)00024-8
BindingDB Entry DOI: 10.7270/Q2S75GBB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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 91n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of matrix metalloproteinase-2

Bioorg Med Chem Lett 6: 329-332 (1996)


Article DOI: 10.1016/0960-894X(96)00024-8
BindingDB Entry DOI: 10.7270/Q2S75GBB
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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n/an/a 34n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix Metallo Proteinase-1(MMP-1)

Bioorg Med Chem Lett 6: 1725-1730 (1996)


Article DOI: 10.1016/0960-894X(96)00304-6
BindingDB Entry DOI: 10.7270/Q2057FW1
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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n/an/a 91n/an/an/an/an/an/a



Glaxo Incorporated Research Institute

Curated by ChEMBL


Assay Description
Activity against human stromelysin (MMP-3).

J Med Chem 37: 674-88 (1994)


BindingDB Entry DOI: 10.7270/Q2RV0MRC
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Glaxo Incorporated Research Institute

Curated by ChEMBL


Assay Description
Activity against human gelatinase (MMP-9).

J Med Chem 37: 674-88 (1994)


BindingDB Entry DOI: 10.7270/Q2RV0MRC
More data for this
Ligand-Target Pair
Stromelysin-1


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against Matrix metalloproteinase-3

Bioorg Med Chem Lett 6: 379-384 (1996)


Article DOI: 10.1016/0960-894X(96)00028-5
BindingDB Entry DOI: 10.7270/Q2CZ374H
More data for this
Ligand-Target Pair
Interstitial collagenase


(Homo sapiens (Human))		BDBM50040594
PNG
((R)-4-(1,3-Dioxo-1,3-dihydro-benzo[f]isoindol-2-yl...)
Show SMILES CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)N[C@H](CCN1C(=O)c2cc3ccccc3cc2C1=O)C(O)=O
Show InChI InChI=1S/C32H36N4O6/c1-19(2)15-26(29(38)35-27(28(37)33-3)16-20-9-5-4-6-10-20)34-25(32(41)42)13-14-36-30(39)23-17-21-11-7-8-12-22(21)18-24(23)31(36)40/h4-12,17-19,25-27,34H,13-16H2,1-3H3,(H,33,37)(H,35,38)(H,41,42)/t25-,26+,27+/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Glaxo Incorporated Research Institute

Curated by ChEMBL


Assay Description
Activity against human collagenase (MMP-1).

J Med Chem 37: 674-88 (1994)


BindingDB Entry DOI: 10.7270/Q2RV0MRC
More data for this
Ligand-Target Pair