BindingDB PrimarySearch

BDBM50040961 CHEMBL3354952

SMILES: [H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO

InChI Key: InChIKey=NORCYAGQZVMECV-MWLCHTKSSA-N

Data: 2 IC50 10 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50040961
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]Astemizole from human ERG channel				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human ERG channel by patch clamp technique				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (MOUSE)	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.87E+4	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at mouse recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Mus musculus (Mouse))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at mouse recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at recombinant rat CB1 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...				ACS Med Chem Lett 8: 1309-1313 (2017) Article DOI: 10.1021/acsmedchemlett.7b00396 BindingDB Entry DOI: 10.7270/Q25D8VCM
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Rattus norvegicus (Rat))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at rat recombinant CB2 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Rattus norvegicus (rat))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at rat recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Homo sapiens (Human))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	64	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at recombinant human CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 ...				ACS Med Chem Lett 8: 1309-1313 (2017) Article DOI: 10.1021/acsmedchemlett.7b00396 BindingDB Entry DOI: 10.7270/Q25D8VCM
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 2 (Rattus norvegicus (Rat))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at recombinant rat CB2 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 hr...				ACS Med Chem Lett 8: 1309-1313 (2017) Article DOI: 10.1021/acsmedchemlett.7b00396 BindingDB Entry DOI: 10.7270/Q25D8VCM
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at recombinant human CB1 receptor expressed in HEK293 cells assessed as increase in beta arrestin recruitment measured after 2 to 3 ...				ACS Med Chem Lett 8: 1309-1313 (2017) Article DOI: 10.1021/acsmedchemlett.7b00396 BindingDB Entry DOI: 10.7270/Q25D8VCM
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair
Cannabinoid receptor 1 (Homo sapiens (Human))	BDBM50040961 (CHEMBL3354952) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Agonist activity at human recombinant CB1 receptor expressed in CHOK1 cells assessed as cAMP accumulation by HTRF method				Bioorg Med Chem Lett 25: 322-6 (2014) Article DOI: 10.1016/j.bmcl.2014.11.040 BindingDB Entry DOI: 10.7270/Q21J9CDS
Arena Pharmaceuticals Curated by ChEMBL					More data for this Ligand-Target Pair