BDBM50042548 5-Butyl-2-(3-chloro-phenyl)-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-pyrazole-3-carboxylic acid ethyl ester::CHEMBL93289
SMILES: CCCCc1nn(c(C(=O)OCC)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1cccc(Cl)c1
InChI Key: InChIKey=OQFCGMYXNSPJFQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Renal dipeptidase (GUINEA PIG) | BDBM50042548 (5-Butyl-2-(3-chloro-phenyl)-4-[2'-(1H-tetrazol-5-y...) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 4.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro apparent inhibition constant of porcine renal Dehydropeptidase-1. | Bioorg Med Chem Lett 9: 2741-6 (1999) BindingDB Entry DOI: 10.7270/Q24Q7T6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II type 1a (AT-1a) receptor (RABBIT) | BDBM50042548 (5-Butyl-2-(3-chloro-phenyl)-4-[2'-(1H-tetrazol-5-y...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1 | J Med Chem 36: 3595-605 (1994) BindingDB Entry DOI: 10.7270/Q25Q4V5H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-lactamase type II (Bacteroides fragilis) | BDBM50042548 (5-Butyl-2-(3-chloro-phenyl)-4-[2'-(1H-tetrazol-5-y...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of metallo-beta-lactamase (MBL) from Bacteroides fragilis. | Bioorg Med Chem Lett 9: 2741-6 (1999) BindingDB Entry DOI: 10.7270/Q24Q7T6C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
metallo-beta-lactamase IMP-1 (Pseudomonas aeruginosa) | BDBM50042548 (5-Butyl-2-(3-chloro-phenyl)-4-[2'-(1H-tetrazol-5-y...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 7.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of metallo-beta-lactamase (MBL) from Pseudomonas aeruginosa mediated by the plasmid-borne IMP-1 enzyme. | Bioorg Med Chem Lett 9: 2741-6 (1999) BindingDB Entry DOI: 10.7270/Q24Q7T6C | |||||||||||
More data for this Ligand-Target Pair |