BindingDB PrimarySearch

BDBM50042848 CHEMBL3098691

SMILES: ONC(=O)CCCCC[C@H](NC(=O)[C@@H]1CCC(=O)N1)C(=O)Nc1ccccc1

InChI Key: InChIKey=QMGDCUHFYVMSBA-GJZGRUSLSA-N

Data: 14 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50042848
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Curated by ChEMBL					Assay Description Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 25: 459-61 (2015) Article DOI: 10.1016/j.bmcl.2014.12.051 BindingDB Entry DOI: 10.7270/Q2445P3R
					More data for this Ligand-Target Pair
Histone deacetylase 3 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Curated by ChEMBL					Assay Description Inhibition of human HDAC3 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 25: 459-61 (2015) Article DOI: 10.1016/j.bmcl.2014.12.051 BindingDB Entry DOI: 10.7270/Q2445P3R
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Curated by ChEMBL					Assay Description Inhibition of human HDAC6 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 25: 459-61 (2015) Article DOI: 10.1016/j.bmcl.2014.12.051 BindingDB Entry DOI: 10.7270/Q2445P3R
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Curated by ChEMBL					Assay Description Inhibition of human HDAC8 using RHK(Ac)K(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 25: 459-61 (2015) Article DOI: 10.1016/j.bmcl.2014.12.051 BindingDB Entry DOI: 10.7270/Q2445P3R
					More data for this Ligand-Target Pair
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	113	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Curated by ChEMBL					Assay Description Inhibition of human HDAC10 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 25: 459-61 (2015) Article DOI: 10.1016/j.bmcl.2014.12.051 BindingDB Entry DOI: 10.7270/Q2445P3R
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Curated by ChEMBL					Assay Description Inhibition of human HDAC11 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 25: 459-61 (2015) Article DOI: 10.1016/j.bmcl.2014.12.051 BindingDB Entry DOI: 10.7270/Q2445P3R
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of human HDAC8 using RHK(Ac)K(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 24: 61-4 (2014) Article DOI: 10.1016/j.bmcl.2013.11.072 BindingDB Entry DOI: 10.7270/Q21839GT
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of human HDAC3/NCOR2 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 24: 61-4 (2014) Article DOI: 10.1016/j.bmcl.2013.11.072 BindingDB Entry DOI: 10.7270/Q21839GT
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of human HDAC1 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 24: 61-4 (2014) Article DOI: 10.1016/j.bmcl.2013.11.072 BindingDB Entry DOI: 10.7270/Q21839GT
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of human HDAC11 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 24: 61-4 (2014) Article DOI: 10.1016/j.bmcl.2013.11.072 BindingDB Entry DOI: 10.7270/Q21839GT
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of human HDAC6 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 24: 61-4 (2014) Article DOI: 10.1016/j.bmcl.2013.11.072 BindingDB Entry DOI: 10.7270/Q21839GT
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 2 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	143	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of human HDAC2 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 24: 61-4 (2014) Article DOI: 10.1016/j.bmcl.2013.11.072 BindingDB Entry DOI: 10.7270/Q21839GT
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 10 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Inhibition of human HDAC10 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 24: 61-4 (2014) Article DOI: 10.1016/j.bmcl.2013.11.072 BindingDB Entry DOI: 10.7270/Q21839GT
Universit£ degli Studi di Siena Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50042848 (CHEMBL3098691) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
R&D Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Curated by ChEMBL					Assay Description Inhibition of human HDAC1 using RHKK(Ac) as substrate by fluorimetric analysis				Bioorg Med Chem Lett 25: 459-61 (2015) Article DOI: 10.1016/j.bmcl.2014.12.051 BindingDB Entry DOI: 10.7270/Q2445P3R
					More data for this Ligand-Target Pair